| Clinical | Arm A | Arm B |
|---|
| Adverse Events | Grade | Adverse Events | Grade |
|---|
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|
| Asthenia/fatigue | 5/9 | 4 | 1 | | | 3/7 | 2 | 1 | | |
| Headaches | 4/9 | 3 | 1 | | | 6/7 | 5 | 1 | | |
| anorexia | 7/9 | 7 | | | | 3/7 | 3 | | | |
| diarrhoea | 1/9 | 1 | 1 | | | 2/7 | 2 | | | |
| Nausea/vomiting | 1/9 | 1 | | | | 3/7 | 3 | | | |
| Arthralgia | 1/9 | | | 1 | | 5/7 | 1 | 3 | 1 | |
| Insomnia | 6/9 | 4 | 2 | | | 3/7 | 2 | 1 | | |
| vertigo | 5/9 | 4 | 1 | | | 0/7 | | | | |
| Skin rash | 5/9 | 4 | 1 | | | 2/7 | 1 | 1 | | |
| Death | 1/9 | | | | 1 | 1/7 | | | | 1 |
| Laboratory |
| Anaemia | 9/9 | 2 | 3 | 2 | 2 | 7/7 | 3 | 2 | 1 | 1 |
| Leukopenia | 3/9 | 3 | | | | 1/7 | 1 | | | |
| Neutropenia | 1/9 | 1 | | | | 2/7 | 1 | 1 | | |
| Thrombopenia | 0/9 | | | | | 1/7 | | 2 | | |
| ALT elevated | 6/9 | 4 | 2 | | | 0/7 | | | | |
| ASAT elevated | 7/9 | 6 | 1 | | | 3/7 | 3 | | | |
| Amylasemia elevated | 3/9 | 3 | | | | 2/7 | | 2 | | |
| Bilirubinemia T elevated | 4/9 | 4 | | | | 5/7 | 3 | 2 | | |
