Skip to main content

Table 2 Follow-up testing and specimen collection for all participants in the PICASSO 2 study by time of visit, Lima, Peru, 2018–2022

From: Investigation of syphilis immunology and Treponema pallidum subsp. pallidum biology to improve clinical management and design a broadly protective vaccine: study protocol

Test

Baseline

4 weeks

12 weeks

24 weeks

36 weeks

48 weeks

RapidTreponema pallidumantibody test

x

     

Rapid plasma reagina

x

x

x

x

x

x

Treponema pallidum-particle agglutination testb

x

x

x

x

x

x

Whole blood and serum collection

x

x

x

x

x

x

Rapid HIV test

x

x (if previously HIV uninfected)

x (if previously HIV uninfected)

x (if previously HIV uninfected)

x (if previously HIV uninfected)

x (if previously HIV uninfected)

Absolute CD4 count (if HIV infected)

x

x

x

x

x

x

Plasma viral load (if HIV infected)

x

x

x

x

x

x

Lesion swab

x

     

Oropharyngeal swab

x

     
  1. aThe cut-off value for current infection will be set at ≥1:8
  2. bThe Treponema pallidum-particle agglutination test will be used to confirm rapid plasma reagin results using a reactive cutoff value of ≥1:80