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Table 2 Follow-up testing and specimen collection for all participants in the PICASSO 2 study by time of visit, Lima, Peru, 2018–2022

From: Investigation of syphilis immunology and Treponema pallidum subsp. pallidum biology to improve clinical management and design a broadly protective vaccine: study protocol

TestBaseline4 weeks12 weeks24 weeks36 weeks48 weeks
RapidTreponema pallidumantibody testx     
Rapid plasma reaginaxxxxxx
Treponema pallidum-particle agglutination testbxxxxxx
Whole blood and serum collectionxxxxxx
Rapid HIV testxx (if previously HIV uninfected)x (if previously HIV uninfected)x (if previously HIV uninfected)x (if previously HIV uninfected)x (if previously HIV uninfected)
Absolute CD4 count (if HIV infected)xxxxxx
Plasma viral load (if HIV infected)xxxxxx
Lesion swabx     
Oropharyngeal swabx     
  1. aThe cut-off value for current infection will be set at ≥1:8
  2. bThe Treponema pallidum-particle agglutination test will be used to confirm rapid plasma reagin results using a reactive cutoff value of ≥1:80