TY - JOUR AU - Osias, Ethan AU - Hung, Phoebe AU - Giacani, Lorenzo AU - Stafylis, Chrysovalantis AU - Konda, Kelika A. AU - Vargas, Silver K. AU - Reyes-Díaz, E. Michael AU - Comulada, W. Scott AU - Haake, David A. AU - Haynes, Austin M. AU - Caceres, Carlos F. AU - Klausner, Jeffrey D. PY - 2020 DA - 2020/06/23 TI - Investigation of syphilis immunology and Treponema pallidum subsp. pallidum biology to improve clinical management and design a broadly protective vaccine: study protocol JO - BMC Infectious Diseases SP - 444 VL - 20 IS - 1 AB - The syphilis epidemic continues to cause substantial morbidity and mortality worldwide, particularly in low- and middle-income countries, despite several recent disease control initiatives. Though our understanding of the pathogenesis of this disease and the biology of the syphilis agent, Treponema pallidum subsp. pallidum has improved over the last two decades, further research is necessary to improve clinical diagnosis and disease management protocols. Additionally, such research efforts could contribute to the identification of possible targets for the development of an effective vaccine to stem syphilis spread. SN - 1471-2334 UR - https://doi.org/10.1186/s12879-020-05141-0 DO - 10.1186/s12879-020-05141-0 ID - Osias2020 ER -