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Table 1 Clinical characteristics of patients with carba-S and carba-NS GNB bacteremia

From: Risk factors for and clinical outcomes of carbapenem non-susceptible gram negative bacilli bacteremia in patients with acute myelogenous leukemia

VariablesCarba-S (n = 444)Carba-NS (n = 45)P
Age, mean (± SD)51.0 (± 14.8)56.4 (± 13.8)0.019
Male263 (59.2)20 (44.4)0.056
Chemotherapy  < 0.001
 Induction or re-induction170 (38.3)33 (73.3) 
 Consolidation274 (61.7)12 (26.7) 
Diabetes mellitus123 (27.7)13 (28.9)0.866
Isolation of resistant organism in the prior 1 year
 VRE33 (7.4)11 (24.4)0.001
 ESBL22 (5.0)7 (15.6)0.011
 CRPA9 (2.0)2 (4.4)0.268
 CRAB3 (0.7)6 (13.3)< 0.001
History of GNB bacteremia in the prior 1 year146 (32.9)21 (46.7)0.063
Presence of preceding bacteremia during the hospitalization42 (9.5)19 (42.2)< 0.001
Primary foci of infection
 Intra-abdominal infection67 (15.1)5 (11.1)0.473
 Central line associated infection52 (11.7)9 (20.0)0.086
 Urinary tract infection8 (1.8)0 (0.0)1.000
 Pneumonia6 (1.4)0 (0.0)1.000
 Others9 (2.0)0 (0.0)0.610
 Unknown303 (68.2)31 (68.9)0.929
Pitt score, median (IQR)1.6 (0.0–2.0)2.2 (0.0–4.0)0.171
Septic shock92 (20.7)10 (22.2)0.813
Microorganism
E.coli196 (44.1)0 (0.0)< 0.001
Klebsiella spp.127 (28.6)2 (4.4)a< 0.001
 Other enterobacteriaceae75 (16.9)1 (2.2)a0.010
Pseudomonas spp.36 (8.1)11 (24.4)b0.002
S. maltophilia0 (0.0)23 (51.1)c< 0.001
Acinetobacter spp.4 (0.9)10 (22.2)d< 0.001
 Others32 (7.2)3 (6.7)e0.561
Antibiotics at the onset of GNB bacteremia  < 0.001
 None252 (56.8)4 (8.9) 
 Agents without antipseudomonal activity40 (9.0)2 (4.4) 
 Antipseudomonal agents, not carbapenem147 (33.1)14 (31.1) 
 Carbapenem5 (1.1)25 (55.6) 
Inappropriate empiric antibiotics12 (2.7)28 (62.2)< 0.001
Hospital stay
 Days from chemotherapy to GNB bacteremia, median (IQR)14 (11–16)22 (16–29)< 0.001
 Hospital days to GNB bacteremia, median (IQR)22 (14–20)39 (23–53)< 0.001
Clinical outcomes
 30-day mortality25 (5.6)16 (35.6)< 0.001
 In-hospital mortality42 (9.5)21 (46.7)< 0.001
  1. Carba-S carbapenem susceptible, Carba-NS carbapenem non-susceptible, SD standard deviation, VRE vancomycin resistant enterococci, ESBL extended-spectrum β-lactamase-producing enterobacteriaceae, CRPA carbapenem resistant Pseudomonas aeruginosa, CRAB carbapenem resistant Acinetobacter baumannii, GNB gram negative bacilli, IQR interquartile range
  2. a One case was mixed GNB bacteremia case
  3. b Three cases were mixed GNB bacteremia cases
  4. c Eight cases were mixed GNB bacteremia cases
  5. d Two cases were mixed GNB bacteremia cases
  6. e Namely, two and one cases were Elizabethkingia meningoseptica, and Burkholderia cepacia, respectively