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Table 1 Clinical characteristics of patients with carba-S and carba-NS GNB bacteremia

From: Risk factors for and clinical outcomes of carbapenem non-susceptible gram negative bacilli bacteremia in patients with acute myelogenous leukemia

Variables

Carba-S (n = 444)

Carba-NS (n = 45)

P

Age, mean (± SD)

51.0 (± 14.8)

56.4 (± 13.8)

0.019

Male

263 (59.2)

20 (44.4)

0.056

Chemotherapy

  

< 0.001

 Induction or re-induction

170 (38.3)

33 (73.3)

 

 Consolidation

274 (61.7)

12 (26.7)

 

Diabetes mellitus

123 (27.7)

13 (28.9)

0.866

Isolation of resistant organism in the prior 1 year

 VRE

33 (7.4)

11 (24.4)

0.001

 ESBL

22 (5.0)

7 (15.6)

0.011

 CRPA

9 (2.0)

2 (4.4)

0.268

 CRAB

3 (0.7)

6 (13.3)

< 0.001

History of GNB bacteremia in the prior 1 year

146 (32.9)

21 (46.7)

0.063

Presence of preceding bacteremia during the hospitalization

42 (9.5)

19 (42.2)

< 0.001

Primary foci of infection

 Intra-abdominal infection

67 (15.1)

5 (11.1)

0.473

 Central line associated infection

52 (11.7)

9 (20.0)

0.086

 Urinary tract infection

8 (1.8)

0 (0.0)

1.000

 Pneumonia

6 (1.4)

0 (0.0)

1.000

 Others

9 (2.0)

0 (0.0)

0.610

 Unknown

303 (68.2)

31 (68.9)

0.929

Pitt score, median (IQR)

1.6 (0.0–2.0)

2.2 (0.0–4.0)

0.171

Septic shock

92 (20.7)

10 (22.2)

0.813

Microorganism

E.coli

196 (44.1)

0 (0.0)

< 0.001

Klebsiella spp.

127 (28.6)

2 (4.4)a

< 0.001

 Other enterobacteriaceae

75 (16.9)

1 (2.2)a

0.010

Pseudomonas spp.

36 (8.1)

11 (24.4)b

0.002

S. maltophilia

0 (0.0)

23 (51.1)c

< 0.001

Acinetobacter spp.

4 (0.9)

10 (22.2)d

< 0.001

 Others

32 (7.2)

3 (6.7)e

0.561

Antibiotics at the onset of GNB bacteremia

  

< 0.001

 None

252 (56.8)

4 (8.9)

 

 Agents without antipseudomonal activity

40 (9.0)

2 (4.4)

 

 Antipseudomonal agents, not carbapenem

147 (33.1)

14 (31.1)

 

 Carbapenem

5 (1.1)

25 (55.6)

 

Inappropriate empiric antibiotics

12 (2.7)

28 (62.2)

< 0.001

Hospital stay

 Days from chemotherapy to GNB bacteremia, median (IQR)

14 (11–16)

22 (16–29)

< 0.001

 Hospital days to GNB bacteremia, median (IQR)

22 (14–20)

39 (23–53)

< 0.001

Clinical outcomes

 30-day mortality

25 (5.6)

16 (35.6)

< 0.001

 In-hospital mortality

42 (9.5)

21 (46.7)

< 0.001

  1. Carba-S carbapenem susceptible, Carba-NS carbapenem non-susceptible, SD standard deviation, VRE vancomycin resistant enterococci, ESBL extended-spectrum β-lactamase-producing enterobacteriaceae, CRPA carbapenem resistant Pseudomonas aeruginosa, CRAB carbapenem resistant Acinetobacter baumannii, GNB gram negative bacilli, IQR interquartile range
  2. a One case was mixed GNB bacteremia case
  3. b Three cases were mixed GNB bacteremia cases
  4. c Eight cases were mixed GNB bacteremia cases
  5. d Two cases were mixed GNB bacteremia cases
  6. e Namely, two and one cases were Elizabethkingia meningoseptica, and Burkholderia cepacia, respectively
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BMC Infectious Diseases

ISSN: 1471-2334

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