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Table 2 The prevalence of cryptococcal antigemia and distribution of other clinical features of the study participants, 2007–2018

From: Cryptococcal antigenemia and its predictors among HIV infected patients in resource limited settings: a systematic review

Author (s)

Median CD4 count (cells/μl)

ART status

WHO stage IV (%)

Had headache (%)

+ CrAg test, n (%)

Vidal et al. [28]

25

74% on ART

66

No data

5 (3.1)

Ganiem et al. [29]

20

All naïve

no data

No data

58 (7.1)

Cheryl et al. [30]

50

All naïve

36.2

No data

22 (5.8)

Beyene et al. [31]

-*

47.6% on ATR

36.2

45.7

26 (10.2)

Meya et al. [32]

79

All naïve

No data

45.7

50 (8.2)

Rugemalila et al. [33]

96

44% on ART

No data

66

7 (3)

Longley et al. [34]

55.5

All naïve

No data

No data

28 (4.3)

Hailu et al. [35]

-**

52% on ART

45

33

9 (3.4)

Letang et al. [36]

71

All naïve

No data

No data

28 (3.7)

Christopher et al. [37]

-***

All on ART

No data

No data

33 (9.9)

Williams et al. [38]

25

51% on ART

No data

No data

149 (72)^

Alemu et al. [39]

123

74% on ART

100

28

31 (8.4)

Derbie et al. [40]

51.8

All on ART

No data

No data

16 (11.7)

Mamuye et al. [41]

93

51% on ART

36%

39

18 (9.1)

Oyella et al. [42]

23

All naïve

No data

37.1

69 (19)

Ogouyemi et al. [18]

-**

All naïve

No data

No data

6 (1.7)

Drain et al. [43]

75

All naïve

No data

No data

39 (9)

Mdodo et al. [44]

72

30.6% on ART

No data

80.6

111 (33)

Micol et al. [45]

24

All naïve

28%

52.5

59 (18)

Jarvis et al. [46]

97

All naïve

No data

No data

46 (7)

Wajanga et al. [47]

68

All naïve

17.9%

No data

17 (5.1)

Magambo et al. [48]

97

All naïve

66

10

10 (7.1)

  1. Four studies didn’t report the exact median CD4 count of their study participants. However, *about 59 (23.2%) of this particular study participants had CD4 < 100; **All the study participants of this study had CD4 count < 100; *** About 121(36.3%) of this study participants had CD4 < 200
  2. ^Outlier: subjects were HIV patients suspected for meningitis who were admitted to a hospital. The figure is excluded from the pooled prevalence analysis