With Candidemia N = 70 (%) | Without Candidemia N = 70 (%) | Total N = 140 (%) | p | |
---|---|---|---|---|
Age (mean ± SD) | 67.04 ± 14.58 | 64.91 ± 14.71 | 65.98 ± 14.63 | 0.391 |
Sex | ||||
Female | 30 (42.9) | 32 (45.7) | 62 (44.3) | 0.734 |
Male | 40 (57.1) | 38 (54.3) | 78 (55.7) | |
MaCabe classification | 0.007 | |||
Non-fatal | 13 (18.6) | 27 (38.6) | 40 (28.6) | |
Ultimately fatal | 53 (75.7) | 43 (61.4) | 96 (68.6) | |
Rapidly fatal | 4 (5.7) | 0 (0.0) | 4 (2.9) | |
Immunosuppressant | 7 (10.0) | 1 (1.4) | 8 (5.7) | 0.063 |
Use of steroid | 2 (2.9) | 1 (1.4) | 3 (2.1) | 1.000 |
Underlying diseases | ||||
Solid cancer | 27 (38.6) | 32 (45.7) | 59 (42.1) | 0.392 |
Neurologic diseases | 32 (45.7) | 20 (28.6) | 52 (37.1) | 0.036 |
Diabetes mellitus | 22 (31.4) | 22 (31.4) | 44 (31.4) | 1.000 |
Cardiovascular diseases | 16 (22.9) | 8 (11.4) | 24 (17.1) | 0.073 |
Chronic kidney disease | 8 (11.4) | 7 (10.0) | 15 (10.7) | 0.785 |
Chronic liver disease | 7 (10.5) | 8 (11.4) | 15 (10.7) | 1.000 |
Chronic lung diseases | 2 (2.9) | 5 (7.1) | 7 (5.0) | 0.245 |
Lymphoma | 4 (5.7) | 0 (0.0) | 4 (2.9) | 0.120 |
Solid organ transplantation | 1 (1.4) | 1 (1.4) | 2 (1.4) | 1.000 |
Site of infection | ||||
Catheter related infection | 48 (68.6) | 0 (0.0) | 48 (34.3) | < 0.001 |
Pneumonia | 0 (0.0) | 31 (42.9) | 31 (22.1) | < 0.001 |
Primary bacteremia | 20 (28.6) | 0 (0.0) | 20 (14.3) | < 0.001 |
Intra-abdominal infection | 1 (1.4) | 12 (17.1) | 13 (9.3) | 0.002 |
Skin and soft tissue infection | 0 (0.0) | 13 (18.6) | 13 (9.3) | < 0.001 |
Urinary tract infection | 1 (1.4) | 8 (11.4) | 9 (6.4) | 0.033 |
CNS infection | 0 (0.0) | 1 (1.4) | 1 (0.7) | 1.000 |
Non-infectious SIRS | 0 (0.0) | 5 (7.1) | 5 (3.6) | 0.058 |
Severity of infection | ||||
Pitt bacteremia score (median, IQR) | 0 (0.0–3.0) | 0 (0.0–2.0) | 0 (0.0–3.0) | 0.561 |
Severe sepsis | 9 (12.9) | 5 (7.1) | 14 (10.0) | 0.485 |
Septic shock | 18 (25.7) | 17 (24.3) | 35 (25.0) | |
Total parenteral nutrition | 25 (35.7) | 17 (24.3) | 42 (30.0) | 0.140 |
Operation | 20 (28.6) | 37 (52.9) | 57 (40.7) | 0.003 |
Candia colonization | 19 (27.1) | 6 (8.6) | 25 (17.9) | 0.004 |