TY - JOUR AU - Sayadi, Mahdieh AU - Zare, Hosna AU - Jamedar, Saeed Amel AU - Hashemy, Seyed Isaac AU - Meshkat, Zahra AU - Soleimanpour, Saman AU - Hoffner, Sven AU - Ghazvini, Kiarash PY - 2020 DA - 2020/06/01 TI - Genotypic and phenotypic characterization of Mycobacterium tuberculosis resistance against fluoroquinolones in the northeast of Iran JO - BMC Infectious Diseases SP - 390 VL - 20 IS - 1 AB - Fluoroquinolones are broad-spectrum antibiotics that are recommended, and increasingly important, for the treatment of multidrug-resistant tuberculosis (MDR-TB). Resistance to fluoroquinolones is caused by mutations in the Quinolone Resistance Determining Region (QRDR) of gyrA and gyrB genes of Mycobacterium tuberculosis. In this study, we characterized the phenotypic and genotypic resistance to fluoroquinolones for the first time in northeast Iran. SN - 1471-2334 UR - https://doi.org/10.1186/s12879-020-05112-5 DO - 10.1186/s12879-020-05112-5 ID - Sayadi2020 ER -