Table 3 Haplotypes of drug resistance genes, that exist at a prevalence of more than 5%, among imported P. falciparum cases in Qatar. Haplotypes are shown as amino acids (wild-type in normal case, substitutions in bold underlined)
Locus | Genotype | Haplotype | Prevalence | the Indian subcontinent (n = 7) | Africa (n = 63) | P value |
|---|---|---|---|---|---|---|
Pfcrt | Wild type | C72 K76 A220 Q271 N326 I356 R371 | 44% | 1(14%) | 30(48%) | 0.1233 |
Mutant | C72 K76S220E271 N326 I356 R371 | 13% | 6(85%) | 33(52%) | Â | |
Mutant | C/S72T76S220E271 N326 I356 R371 | 5% | ||||
Mutant | C72 K76S220E271S326 I356 R371 | 29% | ||||
Pfmdr1 | Wild type | N86 F184 F938 G968 D1246 | 39% | 4(57%) | 23(37%) | 0.4118 |
Mutant | N86Y184 F938G968 D1246 | 10% | 3(43%) | 43(68%) | Â | |
Mutant | Y86 F184 F938 G968 D1246 | 30% | ||||
PfK13 | Wild type | H136 T149 K189 N217 R255 E433G453 | 47% | 7(100%) | 26(41%) | 0.0036 |
Mutant | H136 T149T189 N217 R255 E433 G453 | 34% | 0(0%) | 37(59%) | Â | |
Pfmrp1 | Wild type | H191K202S437I876L1342F1390 K1466D1533 | 31% | 1(14%) | 21(33%) | 0.4201 |
Mutant | H191K202S437V876L1342F1390 K1466D1533 | 6% | 6(86%) | 42(67%) | Â | |
Mutant | H191K202S437V876L1342F1390R1466D1533 | 10% | ||||
Mutant | Y191K202A437V876L1342I1390 K1466D1533 | 5% |