Influx of diverse, drug resistant and transmissible Plasmodium falciparum into a malaria-free setting in Qatar

BMC Infectious Diseases

Table 3 Haplotypes of drug resistance genes, that exist at a prevalence of more than 5%, among imported P. falciparum cases in Qatar. Haplotypes are shown as amino acids (wild-type in normal case, substitutions in bold underlined)

Locus	Genotype	Haplotype	Prevalence	the Indian subcontinent (n = 7)	Africa (n = 63)	P value
Pfcrt	Wild type	C₇₂ K₇₆ A₂₂₀ Q₂₇₁ N₃₂₆ I₃₅₆ R₃₇₁	44%	1(14%)	30(48%)	0.1233
	Mutant	C₇₂ K₇₆S₂₂₀E₂₇₁ N₃₂₆ I₃₅₆ R₃₇₁	13%	6(85%)	33(52%)
	Mutant	C/S₇₂T₇₆S₂₂₀E₂₇₁ N₃₂₆ I₃₅₆ R₃₇₁	5%
	Mutant	C₇₂ K₇₆S₂₂₀E₂₇₁S₃₂₆ I₃₅₆ R₃₇₁	29%
Pfmdr1	Wild type	N₈₆ F₁₈₄ F₉₃₈ G₉₆₈ D₁₂₄₆	39%	4(57%)	23(37%)	0.4118
	Mutant	N₈₆Y₁₈₄ F₉₃₈G₉₆₈ D₁₂₄₆	10%	3(43%)	43(68%)
	Mutant	Y₈₆ F₁₈₄ F₉₃₈ G₉₆₈ D₁₂₄₆	30%	3(43%)	43(68%)
PfK13	Wild type	H₁₃₆ T₁₄₉ K₁₈₉ N_{217 R255} E₄₃₃G₄₅₃	47%	7(100%)	26(41%)	0.0036
PfK13	Mutant	H_{136 T149}T₁₈₉ N₂₁₇ R₂₅₅ E₄₃₃ G₄₅₃	34%	0(0%)	37(59%)
Pfmrp1	Wild type	H₁₉₁K₂₀₂S₄₃₇I₈₇₆L₁₃₄₂F₁₃₉₀ K₁₄₆₆D₁₅₃₃	31%	1(14%)	21(33%)	0.4201
	Mutant	H₁₉₁K₂₀₂S₄₃₇V₈₇₆L₁₃₄₂F₁₃₉₀ K₁₄₆₆D₁₅₃₃	6%	6(86%)	42(67%)
	Mutant	H₁₉₁K₂₀₂S₄₃₇V₈₇₆L₁₃₄₂F₁₃₉₀R₁₄₆₆D₁₅₃₃	10%
	Mutant	Y₁₉₁K₂₀₂A₄₃₇V₈₇₆L₁₃₄₂I₁₃₉₀ K₁₄₆₆D₁₅₃₃	5%

ISSN: 1471-2334