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Table 3 Haplotypes of drug resistance genes, that exist at a prevalence of more than 5%, among imported P. falciparum cases in Qatar. Haplotypes are shown as amino acids (wild-type in normal case, substitutions in bold underlined)

From: Influx of diverse, drug resistant and transmissible Plasmodium falciparum into a malaria-free setting in Qatar

Locus Genotype Haplotype Prevalence the Indian subcontinent (n = 7) Africa (n = 63) P value
Pfcrt Wild type C72 K76 A220 Q271 N326 I356 R371 44% 1(14%) 30(48%) 0.1233
Mutant C72 K76S220E271 N326 I356 R371 13% 6(85%) 33(52%)  
Mutant C/S72T76S220E271 N326 I356 R371 5%
Mutant C72 K76S220E271S326 I356 R371 29%
Pfmdr1 Wild type N86 F184 F938 G968 D1246 39% 4(57%) 23(37%) 0.4118
Mutant N86Y184 F938G968 D1246 10% 3(43%) 43(68%)  
Mutant Y86 F184 F938 G968 D1246 30%
PfK13 Wild type H136 T149 K189 N217 R255 E433G453 47% 7(100%) 26(41%) 0.0036
Mutant H136 T149T189 N217 R255 E433 G453 34% 0(0%) 37(59%)  
Pfmrp1 Wild type H191K202S437I876L1342F1390 K1466D1533 31% 1(14%) 21(33%) 0.4201
Mutant H191K202S437V876L1342F1390 K1466D1533 6% 6(86%) 42(67%)  
Mutant H191K202S437V876L1342F1390R1466D1533 10%
Mutant Y191K202A437V876L1342I1390 K1466D1533 5%