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Table 1 Description of the study population according to the liver cirrhosis status

From: Diagnostic performance of APRI and FIB-4 for confirming cirrhosis in Indonesian HIV/HCV co-infected patients

 

Total (n = 223)

Non-cirrhosis (LSM < 12.5 kPa) (n = 159)

Cirrhosis (LSM ≥ 12.5 kPa) (n = 64)

p value

Socio-demographic characteristics

 Age, years, mean (SD)

37 (5)

37 (5)

38 (6)

0.376

 Male, n(%)

204 (91.5)

142 (89.3)

62 (96.8)

0.068

 BMI, kg/m2, mean (SD)

22.55 (3.80)

22.26 (3.56)

23.27 (4.27)

0.071

 IVDU history, n(%)

208 (93.3)

148 (93.1)

60 (93.7)

0.857

 Alcohol history, n(%)

159 (71.3)

114 (71.7)

45 (70.3)

0.836

 HBsAg seropositivity, n(%)

8 (3.6)

7 (4.4)

1 (1.5)

0.303

HIV characteristics

 ART duration, years, median (IQR)

6.8 (4)

6.8 (5)

6.8 (2)

0.264

 Current CD4, cells/mm3, median (IQR)

508 (306)

508 (333)

508 (215)

0.855

ART used

 2NRTI + EFV, n(%)

96 (43)

76 (47.7)

20 (31.2)

0.011

 2NRTI + NVP, n(%)

94 (42.2)

64 (40.2)

30 (46.8)

 2NRTI + LPV/r, n(%)

33 (14.8)

19 (11.9)

14 (21.8)

HCV infection characteristics

 HCV-RNA, log10, mean (SD)

6.12 (0.81)

6.15 (0.84)

6.06 (0.73)

0.453

 Hemoglobin, g/dL, mean (SD)

13.8 (2.3)

13.9 (2.0)

13.5 (2.8)

0.201

 Platelet, 103/mL, median (IQR)

225 (77)

249 (78)

173 (72)

< 0.001

 ALT, U/L, median (IQR)

55 (51)

50 (41)

66.5 (71)

< 0.001

 AST, U/L, median (IQR)

41 (41)

37 (25)

71 (64)

< 0.001

 eGFR (CKD-EPI), mL/min/1.73 m2, mean (SD)

108.5 (21.3)

108.5 (20.7)

108.5 (23.0)

0.998

 LSM (kPa), median (IQR)

8.8 (7.3)

7.8 (3.8)

20.1 (10.4)

< 0.001

 APRI score, median (IQR)

0.41 (0.52)

0.34 (0.33)

0.97 (1.25)

< 0.001

 FIB-4 score, median (IQR)

0.88 (0.73)

0.81 (0.45)

1.69 (1.76)

< 0.001

  1. SD: standard deviation; BMI: body mass index; IVDU: intravenous drug user; NRTI: nucleoside reverse transcriptase inhibitor; EFV: efavirenz; NVP: nevirapine; LPV/r: lopinavir/ritonavir; HCV-RNA: Hepatitis C virus-ribonucleic acid; ALT: alanine aminotransferase; AST: aspartate aminotransferase; eGFR: estimated glomerular filtration rate; CKD-EPI: chronic kidney disease-epidemiology collaboration; LSM: liver stiffness measurement; APRI: AST to platelet ratio index; FIB-4: the fibrosis-4 index; IQR: interquartile range; SD: standard deviation; kPa: kilo pascal