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Table 1 Description of the study population according to the liver cirrhosis status

From: Diagnostic performance of APRI and FIB-4 for confirming cirrhosis in Indonesian HIV/HCV co-infected patients

 Total (n = 223)Non-cirrhosis (LSM < 12.5 kPa) (n = 159)Cirrhosis (LSM ≥ 12.5 kPa) (n = 64)p value
Socio-demographic characteristics
 Age, years, mean (SD)37 (5)37 (5)38 (6)0.376
 Male, n(%)204 (91.5)142 (89.3)62 (96.8)0.068
 BMI, kg/m2, mean (SD)22.55 (3.80)22.26 (3.56)23.27 (4.27)0.071
 IVDU history, n(%)208 (93.3)148 (93.1)60 (93.7)0.857
 Alcohol history, n(%)159 (71.3)114 (71.7)45 (70.3)0.836
 HBsAg seropositivity, n(%)8 (3.6)7 (4.4)1 (1.5)0.303
HIV characteristics
 ART duration, years, median (IQR)6.8 (4)6.8 (5)6.8 (2)0.264
 Current CD4, cells/mm3, median (IQR)508 (306)508 (333)508 (215)0.855
ART used
 2NRTI + EFV, n(%)96 (43)76 (47.7)20 (31.2)0.011
 2NRTI + NVP, n(%)94 (42.2)64 (40.2)30 (46.8)
 2NRTI + LPV/r, n(%)33 (14.8)19 (11.9)14 (21.8)
HCV infection characteristics
 HCV-RNA, log10, mean (SD)6.12 (0.81)6.15 (0.84)6.06 (0.73)0.453
 Hemoglobin, g/dL, mean (SD)13.8 (2.3)13.9 (2.0)13.5 (2.8)0.201
 Platelet, 103/mL, median (IQR)225 (77)249 (78)173 (72)< 0.001
 ALT, U/L, median (IQR)55 (51)50 (41)66.5 (71)< 0.001
 AST, U/L, median (IQR)41 (41)37 (25)71 (64)< 0.001
 eGFR (CKD-EPI), mL/min/1.73 m2, mean (SD)108.5 (21.3)108.5 (20.7)108.5 (23.0)0.998
 LSM (kPa), median (IQR)8.8 (7.3)7.8 (3.8)20.1 (10.4)< 0.001
 APRI score, median (IQR)0.41 (0.52)0.34 (0.33)0.97 (1.25)< 0.001
 FIB-4 score, median (IQR)0.88 (0.73)0.81 (0.45)1.69 (1.76)< 0.001
  1. SD: standard deviation; BMI: body mass index; IVDU: intravenous drug user; NRTI: nucleoside reverse transcriptase inhibitor; EFV: efavirenz; NVP: nevirapine; LPV/r: lopinavir/ritonavir; HCV-RNA: Hepatitis C virus-ribonucleic acid; ALT: alanine aminotransferase; AST: aspartate aminotransferase; eGFR: estimated glomerular filtration rate; CKD-EPI: chronic kidney disease-epidemiology collaboration; LSM: liver stiffness measurement; APRI: AST to platelet ratio index; FIB-4: the fibrosis-4 index; IQR: interquartile range; SD: standard deviation; kPa: kilo pascal
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