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Table 3 C-reactive protein (CRP) and procalcitonin (PCT) value in patients of acute Q fever, scrub typhus, and murine typhus with and without delayed responses to doxycycline treatmenta

From: Serum C-reactive protein and procalcitonin values in acute Q fever, scrub typhus, and murine typhus

 

Treatment to defervescence ≤3 days

Treatment to defervescence > 3 days

p

CRP (mg/L)

 Acute phase (Mean ± SD)

 

72.2 ± 58.2

102.7 ± 77.1

0.041*

> 25

75.9% (85/112)

84.8% (28/33)

0.276

> 50

61.6% (69/112)

75.8% (25/33)

0.135

> 75

40.2% (45/112)

51.5% (17/33)

0.247

> 100

26.8% (30/112)

45.5% (15/33)

0.042*

> 150

8.0% (9/112)

21.2% (7/33)

0.053

> 200

2.7% (3/112)

9.1% (3/33)

0.131

 Convalescent phaseb (Mean ± SD)

 

3.6 ± 13.1

19.1 ± 37.4

0.049*

> 25

3.2% (2/62)

15.4% (4/26)

0.060

> 50

1.6% (1/62)

15.4% (4/26)

0.025*

> 75

1.6% (1/62)

7.7% (2/26)

0.207

> 100

0% (0/62)

3.8% (1/26)

0.295

PCT (ng/mL)

 Acute phase (Mean ± SD)

 

0.98 ± 1.40

1.39 ± 1.56

0.167

> 0.25

70.0% (70/100)

77.4% (24/31)

0.423

> 0.5

47.0% (47/100)

58.1% (18/31)

0.282

> 1.0

26.0% (26/100)

48.4% (15/31)

0.019*

> 1.5

20.0% (20/10)

29.0% (9/31)

0.290

> 2.0

12.0% (12/100)

19.4% (6/31)

0.370

> 4.0

5.0% (5/100)

9.7% (3/31)

0.393

 Convalescent phaseb (Mean ± SD)

 

0.08 ± 0.26

0.39 ± 1.09

0.166

> 0.25

6.9% (5/72)

30.8% (8/26)

0.005*

> 0.5

1.4% (1/72)

19.2% (5/26)

0.005*

> 1.0

1.4% (1/72)

3.8% (1/26)

0.462

> 1.5

1.4% (1/72)

3.8% (1/26)

0.462

> 2.0

1.4% (1/72)

3.8% (1/26)

0.462

  1. SD standard deviation
  2. *p < 0.05 indicates statistical significance
  3. aPatients who received fluoroquinolones or achieved defervescence before intervention of doxycycline treatment were excluded
  4. bTests for the convalescent phase were performed 11–45 days from the disease onset (average, 20.0 ± 5.6 days; median, 19 days)