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Table 3 C-reactive protein (CRP) and procalcitonin (PCT) value in patients of acute Q fever, scrub typhus, and murine typhus with and without delayed responses to doxycycline treatmenta

From: Serum C-reactive protein and procalcitonin values in acute Q fever, scrub typhus, and murine typhus

 Treatment to defervescence ≤3 daysTreatment to defervescence > 3 daysp
CRP (mg/L)
 Acute phase (Mean ± SD) 72.2 ± 58.2102.7 ± 77.10.041*
> 2575.9% (85/112)84.8% (28/33)0.276
> 5061.6% (69/112)75.8% (25/33)0.135
> 7540.2% (45/112)51.5% (17/33)0.247
> 10026.8% (30/112)45.5% (15/33)0.042*
> 1508.0% (9/112)21.2% (7/33)0.053
> 2002.7% (3/112)9.1% (3/33)0.131
 Convalescent phaseb (Mean ± SD) 3.6 ± 13.119.1 ± 37.40.049*
> 253.2% (2/62)15.4% (4/26)0.060
> 501.6% (1/62)15.4% (4/26)0.025*
> 751.6% (1/62)7.7% (2/26)0.207
> 1000% (0/62)3.8% (1/26)0.295
PCT (ng/mL)
 Acute phase (Mean ± SD) 0.98 ± 1.401.39 ± 1.560.167
> 0.2570.0% (70/100)77.4% (24/31)0.423
> 0.547.0% (47/100)58.1% (18/31)0.282
> 1.026.0% (26/100)48.4% (15/31)0.019*
> 1.520.0% (20/10)29.0% (9/31)0.290
> 2.012.0% (12/100)19.4% (6/31)0.370
> 4.05.0% (5/100)9.7% (3/31)0.393
 Convalescent phaseb (Mean ± SD) 0.08 ± 0.260.39 ± 1.090.166
> 0.256.9% (5/72)30.8% (8/26)0.005*
> 0.51.4% (1/72)19.2% (5/26)0.005*
> 1.01.4% (1/72)3.8% (1/26)0.462
> 1.51.4% (1/72)3.8% (1/26)0.462
> 2.01.4% (1/72)3.8% (1/26)0.462
  1. SD standard deviation
  2. *p < 0.05 indicates statistical significance
  3. aPatients who received fluoroquinolones or achieved defervescence before intervention of doxycycline treatment were excluded
  4. bTests for the convalescent phase were performed 11–45 days from the disease onset (average, 20.0 ± 5.6 days; median, 19 days)