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Table 1 Clinical and laboratory details of patients with probable BSI

From: In-depth analysis of T2Bacteria positive results in patients with concurrent negative blood culture: a case series

Patient number

Age range, Gender

Brief History of present illness

T2Bacteria result

Other (+) culture with the same T2-detected pathogen within 21 days

Antibiotics used/ Activity against T2 detected bacterium

Radiologic Findings

Discharge Diagnosis

Patient 1

> 65, M

Blood Pressure 80/40 mmHg, heart rate 120/min, fever 38.3 °C. Dysuria and urinary frequency for 5 days PTA

E. coli

Blood cultureb (−2d)

Urine culture (−2d)

CRO, TZP/Yes

CT negative for renal obstruction

ESBL E coli bacteremia and pyelonephritis

Patient 2

> 65, F

Fever, chills, nausea, dysuria

E. coli

Blood cultureb (−1d)

Urine culture (−1d)

CRO /Yes

Pyelonephritis with

E coli bacteremia

Patient 3

50–64, F

Nausea, vomiting, burning with urination, abdominal and flank pain, fever

E. coli

Urine culture (0d)

CRO, TZP/Yes

Pyelonephritis due to

E. coli

Patient 4

> 65, F

Chills, rigors, dyspnea, dysuria

E. coli

Urine culture (0d)

CRO /Yes

CT: bilateral pyelonephritis

Bilateral E coli pyelonephritis

Patient 5

> 65, F

Fever, nausea, vomiting, abdominal pain and dark foul-smelling urine for 1 week.

E. coli

Urine culture (−1d)

CRO, TZP /Yes

CT: 4 mm obstructing calculus, mild hydroureteronephrosis

Pyelonephritis

due to E coli

Patient 6

> 65, M

Fever, dysuria and sepsis.

E. colia

Urine culture (−1d)

CRO /Yes

CT: Right sided Pyelonephritis

Pyelonephritis due to E coli

Patient 7

> 65, F

Weakness, productive cough, fever, nausea and vomiting. Symptoms started 5 days PTA.

S. aureus

Blood cultureb (−4d)

VAN, CRO, AZM/ Yes

CXR with right lower lobe pneumonia

Influenza B, superimposed

S. aureus pneumonia

Patient 8

50–64, M

Left thigh abscess and sepsis. Had a previous visit for left thigh abscess 1 month ago, which was incised.

S. aureus

Wound incision and drainage culture (−2d) with MRSA

VAN, SAM/Yes

U/S: Subcutaneous edema. No drainable abscess

Left thigh abscess/ MRSA wound infection

Patient 9

> 65, M

Left third finger abscess and fever for 8 days. Cellulitis/abscess in left third finger.

S. aureus

Blood cultureb (−11d)

Finger abscess (−2d)

VAN, TZP/Yes

Finger osteomyelitis,

Bacteremia due to S. aureus

Patient 10

18–49, M

Flank pain, chills, dysuria, hematuria. Initially admitted with obstructing mid ureteral calculus and UTI. Underwent urgent right ureteral stent placement.

K. pneumonia

Urine culture (−3d)

AMP, CRO /Yes

CT: Multifocal abscess formation in the right kidney

Obstructing mid-ureteral calculus with UTI and multifocal kidney abscesses.

Patient 11

> 65, M

Fever, shaking chills and nausea. History of recurrent UTIs and benign prostatic hyperplasia requiring self-catheterization with Foley catheter.

P. aeruginosa

Urine culture (−1d)

VAN, TZP/Yes

Complicated UTI due to P. aeruginosa

  1. aT2Bacteria detected 2 targeted organisms in the sample of this patient. Please also see Table 3. bRefers to a previous blood culture, not the blood culture that was taken at the same time with the T2 blood sample
  2. AMC Amoxicillin-clavulanic, AZM Azithromycin, CFZ Cefazolin, CIP Ciprofloxacin, CRO Ceftriaxone, CT Computed Tomography, F Female, M Male, MEM Meropenem, MRSA Methicillin Resistant S. aureus SAM Ampicillin-Sulbactam, PTA prior to admission, TZM Piperacillin-tazobactam, U/S Ultrasound, UTI Urinary Tract Infection, VAN Vancomycin