Table 4 Median serum levels of the selected cytokines at different time point in participants with and without preventive treatment respectively
aCytokine | Active TB | Non-TB | ||||
|---|---|---|---|---|---|---|
T0 | T1 | p for Wilcoxon signed rank test | T0 | T1 | p for Wilcoxon signed rank test | |
Median value (Q25-Q75) (pg/ml) in treated participants (active TB, n = 12; non-TB, n = 24) | ||||||
 Eotaxin | 69.18 (58.08, 87.05) | 45.18 (36.09,75.64) | 0.021 | 37.14 (26.61, 66.58) | 33.34 (22.22, 48.22) | 0.010 |
 MCP-1(MCAF) | 14.08 (10.57, 20.05) | 11.60 (9.68, 15.26) | 0.052 | 7.91 (5.65, 10.10) | 7.38 (5.01, 12.86) | 0.300 |
 MIP-1β | 50.75 (47.05, 63.37) | 56.63 (50.95, 61.09) | 0.470 | 38.06 (30.83, 44.48) | 49.03 (44.11, 54.68) | < 0.001 |
 SDF-1α | 309.99 (234.09, 339.68) | 229.56 (203.70, 261.91) | 0.007 | 211.88 (190.64, 251.72) | 177.85 (158.87, 220.24) | 0.008 |
 G-CSF | 89.49 (73.15, 97.55) | 71.50 (60.18, 85.92) | 0.110 | 49.40 (36.56, 62.44) | 65.14 (39.89, 78.41) | 0.040 |
 VEGF-A | 46.18 (38.72, 62.85) | 42.22 (28.75, 52.27) | 0.339 | 13.34 (3.37, 23.12) | 6.43 (0.25, 37.39) | 0.187 |
 Basic FGF | 23.62 (20.22, 25.25) | 19.51 (18.79, 21.27) | 0.010 | 11.60 (7.52, 17.13) | 11.28 (6.52, 20.05) | 0.459 |
 IFN-γ | 20.89 (17.76, 33.82) | 19.74 (12.71, 26.54) | 0.021 | 14.41 (9.16, 16.86) | 13.87 (5.52, 16.82) | 0.320 |
 TNF-α | 15.89 (14.22, 17.78) | 15.41 (12.66, 17.78) | 0.349 | 8.97 (7.94, 12.41) | 10.36 (6.77, 13.98) | 0.478 |
 TRAIL | 40.94 (35.11, 44.48) | 36.59 (36.42, 43.32) | 0.733 | 32.11 (30.12, 38.04) | 31.28 (23.18, 37.34) | 0.037 |
 IL-1α | 16.45 (11.86, 22.98) | 13.01 (10.72, 14.53) | 0.015 | 5.51 (3.21, 7.47) | 5.24 (1.52, 14.53) | 0.129 |
 IL-1ra | 173.64 (157.39, 185.69) | 126.44 (114.19, 133.83) | 0.002 | 107.36 (80.87, 150.82) | 95.66 (55.77, 131.74) | 0.009 |
 IL-4 | 2.34 (1.94, 3.01) | 1.61 (1.36, 2.01) | 0.013 | 0.52 (0.39, 1.42) | 0.64 (0.04, 1.55) | 0.575 |
 IL-8 | 6.04 (4.40, 7.19) | 4.05 (3.58, 4.64) | 0.017 | 3.14 (2.15, 4.36) | 2.04 (0.70, 3.34) | < 0.001 |
 IL-9 | 65.00 (53.56, 69.74) | 63.83 (55.94, 77.15) | 0.733 | 30.86 (24.88, 41.36) | 37.00 (31.20, 64.25) | < 0.001 |
 IL-17A | 6.68 (6.05, 8.09) | 5.74 (5.05, 6.21) | 0.034 | 3.90 (2.39, 5.12) | 2.97 (0.57, 5.90) | 0.187 |
Median value (Q25-Q75) (pg/ml) in untreated controls (active TB, n = 9; non-TB, n = 18) | ||||||
 Eotaxin | 86.14 (56.31, 100.06) | 55.38 (39.96, 59.73) | 0.012 | 34.46 (29.40, 37.82) | 28.43 (21.67, 38.27) | 0.265 |
 MCP-1(MCAF) | 12.60 (9.20, 16.31) | 12.17 (11.41, 14.12) | 0.570 | 6.81 (5.14, 9.74) | 6.88 (5.14, 10.16) | 0.212 |
 MIP-1β | 48.10 (38.42, 57.29) | 57.68 (49.97, 59.57) | 0.301 | 38.03 (33.57, 43.83) | 48.19 (35.40, 54.16) | 0.024 |
 SDF-1α | 268.74 (253.62, 357.07) | 223.75 (205.00, 256.94) | 0.039 | 219.86 (181.17, 275.33) | 175.13 (142.03, 225.55) | 0.027 |
 G-CSF | 70.18 (68.86, 89.17) | 78.74 (64.20, 94.98) | 0.820 | 45.96 (39.89, 52.46) | 52.17 (32.71, 62.19) | 0.304 |
VEGF-A | 30.46 (19.20, 52.30) | 27.04 (14.41, 35.17) | 0.496 | 10.62 (3.37, 15.07) | 13.88 (0.25, 27.04) | 0.426 |
Basic FGF | 19.51 (19.51, 27.46) | 19.51 (18.06, 20.92) | 0.055 | 9.91 (7.71, 11.27) | 11.98 (6.93, 15.78) | 0.186 |
IFN-γ | 26.08 (18.59,31.97) | 20.47 (14.40,26.28) | 0.055 | 9.48 (8.21, 14.39) | 9.52 (4.75, 15.24) | 0.702 |
TNF-α | 13.98 (12.53,16.84) | 14.46 (11.81,16.84) | 0.688 | 9.60 (6.47,13.04) | 9.00 (5.07, 11.08) | 0.246 |
TRAIL | 35.54 (34.96,55.72) | 40.35 (38.76,42.93) | 0.820 | 28.38 (20.62, 33.46) | 25.86 (18.61, 32.15) | 0.694 |
IL-1α | 9.96 (8.44, 11.48) | 11.48 (7.68, 14.53) | 0.742 | 4.23 (1.86, 4.92) | 4.32 (1.52,9.96) | 0.096 |
IL-1ra | 164.78 (145.93, 185.71) | 116.49 (111.89, 129.64) | 0.078 | 70.70 (55.80, 128.01) | 89.36 (40.01, 109.54) | 0.265 |
IL-4 | 2.18 (2.01, 2.59) | 1.67 (1.42, 1.87) | 0.027 | 0.35 (0.17, 0.51) | 0.58 (0.05, 1.16) | 0.072 |
IL-8 | 4.75 (3.46, 6.61) | 3.81 (3.22, 4.05) | 0.047 | 2.28 (1.57, 3.16) | 1.91 (0.84, 2.39) | 0.030 |
IL-9 | 58.55 (51.44, 65.08) | 66.41 (58.89, 69.24) | 0.496 | 29.50 (26.06, 32.90) | 35.55 (23.97, 64.91) | 0.003 |
IL-17A | 5.12 (4.50, 5.90) | 5.43 (4.50, 6.05) | 0.578 | 2.47 (1.16, 3.73) | 3.12 (1.16, 4.19) | 0.832 |