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Table 4 Median serum levels of the selected cytokines at different time point in participants with and without preventive treatment respectively

From: Serum level of IL-1ra was associated with the treatment of latent tuberculosis infection in a Chinese population

aCytokineActive TBNon-TB
T0T1p for Wilcoxon signed rank testT0T1p for Wilcoxon signed rank test
Median value (Q25-Q75) (pg/ml) in treated participants (active TB, n = 12; non-TB, n = 24)
 Eotaxin69.18 (58.08, 87.05)45.18 (36.09,75.64)0.02137.14 (26.61, 66.58)33.34 (22.22, 48.22)0.010
 MCP-1(MCAF)14.08 (10.57, 20.05)11.60 (9.68, 15.26)0.0527.91 (5.65, 10.10)7.38 (5.01, 12.86)0.300
 MIP-1β50.75 (47.05, 63.37)56.63 (50.95, 61.09)0.47038.06 (30.83, 44.48)49.03 (44.11, 54.68)< 0.001
 SDF-1α309.99 (234.09, 339.68)229.56 (203.70, 261.91)0.007211.88 (190.64, 251.72)177.85 (158.87, 220.24)0.008
 G-CSF89.49 (73.15, 97.55)71.50 (60.18, 85.92)0.11049.40 (36.56, 62.44)65.14 (39.89, 78.41)0.040
 VEGF-A46.18 (38.72, 62.85)42.22 (28.75, 52.27)0.33913.34 (3.37, 23.12)6.43 (0.25, 37.39)0.187
 Basic FGF23.62 (20.22, 25.25)19.51 (18.79, 21.27)0.01011.60 (7.52, 17.13)11.28 (6.52, 20.05)0.459
 IFN-γ20.89 (17.76, 33.82)19.74 (12.71, 26.54)0.02114.41 (9.16, 16.86)13.87 (5.52, 16.82)0.320
 TNF-α15.89 (14.22, 17.78)15.41 (12.66, 17.78)0.3498.97 (7.94, 12.41)10.36 (6.77, 13.98)0.478
 TRAIL40.94 (35.11, 44.48)36.59 (36.42, 43.32)0.73332.11 (30.12, 38.04)31.28 (23.18, 37.34)0.037
 IL-1α16.45 (11.86, 22.98)13.01 (10.72, 14.53)0.0155.51 (3.21, 7.47)5.24 (1.52, 14.53)0.129
 IL-1ra173.64 (157.39, 185.69)126.44 (114.19, 133.83)0.002107.36 (80.87, 150.82)95.66 (55.77, 131.74)0.009
 IL-42.34 (1.94, 3.01)1.61 (1.36, 2.01)0.0130.52 (0.39, 1.42)0.64 (0.04, 1.55)0.575
 IL-86.04 (4.40, 7.19)4.05 (3.58, 4.64)0.0173.14 (2.15, 4.36)2.04 (0.70, 3.34)< 0.001
 IL-965.00 (53.56, 69.74)63.83 (55.94, 77.15)0.73330.86 (24.88, 41.36)37.00 (31.20, 64.25)< 0.001
 IL-17A6.68 (6.05, 8.09)5.74 (5.05, 6.21)0.0343.90 (2.39, 5.12)2.97 (0.57, 5.90)0.187
Median value (Q25-Q75) (pg/ml) in untreated controls (active TB, n = 9; non-TB, n = 18)
 Eotaxin86.14 (56.31, 100.06)55.38 (39.96, 59.73)0.01234.46 (29.40, 37.82)28.43 (21.67, 38.27)0.265
 MCP-1(MCAF)12.60 (9.20, 16.31)12.17 (11.41, 14.12)0.5706.81 (5.14, 9.74)6.88 (5.14, 10.16)0.212
 MIP-1β48.10 (38.42, 57.29)57.68 (49.97, 59.57)0.30138.03 (33.57, 43.83)48.19 (35.40, 54.16)0.024
 SDF-1α268.74 (253.62, 357.07)223.75 (205.00, 256.94)0.039219.86 (181.17, 275.33)175.13 (142.03, 225.55)0.027
 G-CSF70.18 (68.86, 89.17)78.74 (64.20, 94.98)0.82045.96 (39.89, 52.46)52.17 (32.71, 62.19)0.304
VEGF-A30.46 (19.20, 52.30)27.04 (14.41, 35.17)0.49610.62 (3.37, 15.07)13.88 (0.25, 27.04)0.426
Basic FGF19.51 (19.51, 27.46)19.51 (18.06, 20.92)0.0559.91 (7.71, 11.27)11.98 (6.93, 15.78)0.186
IFN-γ26.08 (18.59,31.97)20.47 (14.40,26.28)0.0559.48 (8.21, 14.39)9.52 (4.75, 15.24)0.702
TNF-α13.98 (12.53,16.84)14.46 (11.81,16.84)0.6889.60 (6.47,13.04)9.00 (5.07, 11.08)0.246
TRAIL35.54 (34.96,55.72)40.35 (38.76,42.93)0.82028.38 (20.62, 33.46)25.86 (18.61, 32.15)0.694
IL-1α9.96 (8.44, 11.48)11.48 (7.68, 14.53)0.7424.23 (1.86, 4.92)4.32 (1.52,9.96)0.096
IL-1ra164.78 (145.93, 185.71)116.49 (111.89, 129.64)0.07870.70 (55.80, 128.01)89.36 (40.01, 109.54)0.265
IL-42.18 (2.01, 2.59)1.67 (1.42, 1.87)0.0270.35 (0.17, 0.51)0.58 (0.05, 1.16)0.072
IL-84.75 (3.46, 6.61)3.81 (3.22, 4.05)0.0472.28 (1.57, 3.16)1.91 (0.84, 2.39)0.030
IL-958.55 (51.44, 65.08)66.41 (58.89, 69.24)0.49629.50 (26.06, 32.90)35.55 (23.97, 64.91)0.003
IL-17A5.12 (4.50, 5.90)5.43 (4.50, 6.05)0.5782.47 (1.16, 3.73)3.12 (1.16, 4.19)0.832
  1. Abbreviation: T0 baseline, T1 At the end of preventive treatment; Q25 25% quantile, Q75 75% quantile, TB tuberculosis
  2. a Those cytokines, which had a significantly higher level in active TB individuals compared with non-TB controls at T0 were selected