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Table 2 Median serum levels of selected cytokines among participants with and without TB occurrence classified by preventive treatment at T0 (Median [Q25-Q75] (pg/ml))

From: Serum level of IL-1ra was associated with the treatment of latent tuberculosis infection in a Chinese population

CytokinesUntreated controlsTreated participants
Active TB (n = 9)Non-TB (n = 18)P for Wilcoxon rank sum testActive TB (n = 12)Non-TB (n = 24)P for Wilcoxon rank sum test
CTACK317.71 (247.15, 392.20)339.63 (288.62, 381.48)0.817245.16 (183.03, 342.38)340.84 (260.21, 385.66)0.164
Eotaxin86.14 (56.31, 100.06)34.46 (29.40, 37.82)< 0.00169.18 (58.08, 87.05)37.14 (26.61, 66.58)0.008
GRO-α88.03 (74.31, 136.90)79.17 (69.80, 84.97)0.227113.26 (100.91, 130.08)69.82 (55.58, 89.86)< 0.001
IP-10564.61 (372.63, 670.62)373.06 (329.38, 525.68)0.173514.05 (380.24, 606.51)438.45 (351.99, 499.43)0.275
MCP-1(MCAF)12.60 (9.20, 16.31)6.81 (5.14, 9.74)0.01714.08 (10.57, 20.05)7.91 (5.65, 10.10)< 0.001
MCP-31.15 (0.30, 1.96)0.83 (0.42, 1.07)0.7381.78 (0.45, 3.59)0.80 (0.43, 1.70)0.354
MIF305.23 (227.36, 405.16)282.69 (255.65, 348.78)0.396318.45 (195.43, 358.95)271.78 (220.06, 312.82)0.322
MIG356.29 (308.93, 590.65)285.33 (179.67, 366.12)0.129371.04 (226.06, 612.31)308.06 (214.66, 428.46)0.430
MIP-1α1.35 (1.17, 1.82)1.18 (0.95, 1.35)0.1001.47 (1.41, 1.85)1.32 (0.94, 1.51)0.024
MIP-1β48.10 (38.42, 57.29)38.03 (33.57, 43.83)0.04850.75 (47.05, 63.37)38.06 (30.83, 44.48)< 0.001
PDGF-BB64.30 (42.51, 198.85)84.51 (26.05, 114.55)0.425146.33 (98.52, 232.85)43.91 (26.70, 71.55)0.001
RANTES1314.40 (677.29, 1607.11)1134.09 (467.87, 1437.52)0.4881194.57 (839.53, 2194.69)762.83 (468.35, 1217.44)0.050
SDF-1α268.74 (253.62, 357.07)219.86 (181.17, 275.33)0.017309.99 (234.09, 339.68)211.88 (190.64, 251.72)0.008
SCF37.10 (27.55, 46.29)47.10 (32.85, 55.57)0.45642.94 (28.96, 50.35)40.35 (26.53, 56.04)0.960
M-CSF33.51 (25.14, 38.47)35.26 (26.15, 49.94)0.70031.64 (22.22,42.16)37.66 (27.04, 50.64)0.275
G-CSF70.18 (68.86, 89.17)45.96 (39.89, 52.46)0.00189.49 (73.15, 97.55)49.40 (36.56, 62.44)< 0.001
GM-CSF0.79 (0.61, 1.25)0.60 (0.01, 1.13)0.2551.03 (0.70, 2.37)0.77 (0.14, 1.33)0.122
VEGF-A30.46 (19.20, 52.30)10.62 (3.37, 15.07)0.00646.18 (38.72, 62.85)13.34 (3.37, 23.12)< 0.001
Basic FGF19.51 (19.51, 27.46)9.91 (7.71, 11.27)< 0.00123.62 (20.22, 25.25)11.60 (7.52, 17.13)< 0.001
β-NGF0.74 (0.38, 0.92)0.47 (0.15, 0.74)0.2260.88 (0.74, 1.51)0.56 (0.28, 0.74)0.002
SCGF-β43,169.60 (38,013.20, 57,726.50)40,842.80 (25,219.40, 45,309.10)0.31643,618.70 (38,251.70, 50,595.10)41,198.40 (34,222.50, 49,973.30)0.513
HGF256.86 (249.02,352.46)227.92 (173.75, 340.78)0.292245.12 (213.87, 301.36)229.34 (160.76, 297.97)0.557
IFN-α25.61 (4.07, 9.52)4.35 (2.73, 4.90)0.0608.14 (6.93, 10.77)4.71 (2.95, 5.85)< 0.001
IFN-γ26.08 (18.59,31.97)9.48 (8.21, 14.39)< 0.00120.89 (17.76, 33.82)14.41 (9.16, 16.86)< 0.001
TNF-α13.98 (12.53,16.84)9.60 (6.47,13.04)0.00915.89 (14.22, 17.78)8.97 (7.94, 12.41)< 0.001
TRAIL35.54 (34.96,55.72)28.38 (20.62, 33.46)0.00240.94 (35.11, 44.48)32.11 (30.12, 38.04)0.019
IL-1α9.96 (8.44, 11.48)4.23 (1.86, 4.92)< 0.00116.45 (11.86, 22.98)5.51 (3.21, 7.47)< 0.001
IL-1β2.90 (2.17, 3.26)1.88 (1.40, 3.69)0.3162.16 (1.59, 3.41)2.10 (1.38, 2.97)0.603
IL-1ra164.78 (145.93, 185.71)70.70 (55.80, 128.01)0.004173.64 (157.39, 185.69)107.36 (80.87, 150.82)< 0.001
IL-2Rα99.66 (83.29, 122.15)95.46 (76.73, 141.57)0.85776.25 (47.30, 115.92)101.79 (67.09, 133.93)0.268
IL-42.18 (2.01, 2.59)0.35 (0.17, 0.51)< 0.0012.34 (1.94, 3.01)0.52 (0.39, 1.42)< 0.001
IL-60.91 (0.56, 1.63)0.65 (0.16, 0.93)0.2461.39 (1.01,2.45)0.91 (0.26, 1.25)0.021
IL-84.75 (3.46, 6.61)2.28 (1.57, 3.16)0.0036.04 (4.40, 7.19)3.14 (2.15, 4.36)< 0.001
IL-958.55 (51.44, 65.08)29.50 (26.06, 32.90)0.00165.00 (53.56, 69.74)30.86 (24.88, 41.36)< 0.001
IL-133.70 (2.31, 3.92)1.94 (1.14, 5.21)0.4402.79 (2.00, 4.69)2.23 (1.59, 4.70)0.314
IL-1641.51 (40.09, 49.67)32.48 (28.14, 53.88)0.34137.98 (22.49, 52.19)32.30 (25.81, 41.78)0.535
IL-17A5.12 (4.50, 5.90)2.47 (1.16, 3.73)0.0136.68 (6.05, 8.09)3.90 (2.39, 5.12)< 0.001
IL-1841.61 (35.17, 57.57)40.37 (30.12, 102.04)0.85733.54 (26.08, 42.52)29.43 (24.75, 58.68)0.801
  1. Abbreviation: T0 baseline, Q25 25% quantile, Q75 75% quantile, TB tuberculosis