Serum level of IL-1ra was associated with the treatment of latent tuberculosis infection in a Chinese population

BMC Infectious Diseases

Table 1 Characteristics of the participants included in the study

	Treated participants			Untreated controls
	Developed active TB during follow-up	Kept healthy during follow-up	p value	Developed active TB during follow-up	Kept healthy during follow-up	p value
Total^a	12	24		9	18
Median age (Q25-Q75) (years)	69.00 (65.00, 72.50)	69.00 (65.00, 73.00)	0.973^b	67.00 (62.00, 70.00)	67.00 (62.00, 70.00)	0.979^b
Gender, n (%)			1.000^c			1.000^d
Male	6 (50.00)	12 (50.00)		7 (77.78)	14 (77.78)
Female	6 (50.00)	12 (50.00)		2 (22.22)	4 (22.22)
Median BMI (Q25-Q75) (Kg/m²)	23.54 (19.67, 26.66)	24.11 (21.71, 27.25)	0.535^b	22.46 (20.69, 23.88)	25.53 (21.81, 28.00)	0.029^b
Fasting blood glucose, n (%)			0.253^d			0.539^d
≥7.0 mmol/L	2 (16.67)	1 (4.17)		0 (0.00)	2 (11.11)
<7.0 mmol/L	10 (83.33)	23 (95.83)		9 (100.00)	16 (88.89)
Median INF-γrelease of QFT (Q25-Q75) (IU/ml)
T0	2.47 (1.76, 5.06)	2.79 (0.90, 4.81)	0.651^b	2.06 (1.52, 2.81)	1.50 (0.92, 3.29)	0.520^b
T1	1.52 (0.91, 3.30)	0.87 (0.18, 1.91)	0.095^b	0.73 (0.63, 1.06)	0.63 (0.23, 1.51)	0.471^b
Classified QFT results at T0 (IU/ml), n (%)
0.35 ~ 0.70	0 (0.00)	4 (16.67)	0.279^d	1 (11.11)	4 (22.22)	0.636^d
≥0.70	12 (100.00)	20 (83.33)		8 (88.89)	14 (77.87)

Abbreviation: BMI body mass index, Q25 25% quantile, Q75 75% quantile, QFT QuantiFERON-TB Gold In-Tube, TB tuberculosis, T0 baseline, T1 At the end of preventive treatment. ^aData might not sum to total because of missing data
^bp for Wilcoxon rank sum test. ^c p for χ² test. ^dp for Fisher’s exact test

ISSN: 1471-2334