Molecular characteristics of Clostridium difficile in children with acute gastroenteritis from Zhejiang

BMC Infectious Diseases

Table 2 Correlations among MLST types, toxin genotypes, and antimicrobial susceptibility patterns of the 186 C. difficile isolates

Antimicrobial agent	Total no. (%) of all the isolates (n = 186)	MLST types (no. [%] of non-susceptible isolates)						Analysis results^b		Toxinotypes^c (no. [%] of non-susceptible isolates)		Analysis results
Antimicrobial agent	Total no. (%) of all the isolates (n = 186)	ST26 (n = 33)	ST35 (n = 21)	ST39 (n = 23)	ST54 (n = 31)	ST152 (n = 21)	Other STs^a (n = 57)	χ²	P value	A⁺B⁺ (n = 145)	A⁻B⁺ (n = 39)	χ²	P value
Clindamycin	159 (85.5)	33 (100.0)	21 (100.0)	18 (78.3)	30 (96.8)	13 (61.9)	44 (77.2)	F	< 0.001	125 (86.2)	34 (87.2)	0.02	0.875
Erythromycin	160 (86.0)	33 (100.0)	21 (100.0)	23 (100.0)	30 (96.8)	7 (33.3)	46 (80.7)	F	< 0.001	120 (82.8)	39 (100.0)	7.78	0.005
Fusidic acid	129 (69.4)	12 (36.4)	15 (71.4)	15 (65.2)	28 (90.3)	20 (95.2)	39 (68.4)	30.18	< 0.001	102 (70.3)	27 (69.2)	0.02	0.893
Rifampin	7 (3.8)	0	0	5 (21.7)	0	1 (4.8)	1 (1.8)	F	0.001	2 (1.4)	5 (12.8)	8.09	0.004
Levofloxacin	148 (79.6)	19 (57.6)	21 (100.0)	16 (69.6)	24 (77.4)	21 (100.0)	47 (82.5)	F	< 0.001	117 (80.7)	30 (76.9)	0.27	0.602
Moxifloxacin	14 (7.5)	0	0	6 (26.1)	0	1 (4.8)	7 (12.3)	F	0.001	3 (2.1)	11 (28.2)	29.26	< 0.001
Gatifloxacin	14 (7.5)	0	0	6 (26.1)	0	1 (4.8)	7 (12.3)	F	0.001	3 (2.1)	11 (28.2)	29.26	< 0.001
Tetracycline	17 (9.1)	0	11 (52.4)	0	1 (3.2)	0	5 (8.8)	F	< 0.001	13 (9.0)	4 (10.3)	0.06	0.805
Metronidazole	0	0	0	0	0	0	0	N/A	N/A	0	0	N/A	N/A
Vancomycin	0	0	0	0	0	0	0	N/A	N/A	0	0	N/A	N/A
PIP-TAZ	0	0	0	0	0	0	0	N/A	N/A	0	0	N/A	N/A
Ciprofloxacin	184 (100.0)	33 (100.0)	21 (100.0)	23 (100.0)	31 (100.0)	21 (100.0)	57 (100.0)	N/A	N/A	145 (100.0)	39 (100.0)	N/A	N/A
MDR	166 (89.2)	33 (100.0)	21 (100.0)	21 (91.3)	30 (96.8)	15 (71.4)	46 (80.7)	F	0.001	129 (89.0)	37 (94.9)	0.64	0.425

^a: Of two non-toxigenic isolates, one (50.0%) was non-susceptible to erythromycin and levofloxacin; both of them (100.0%) were non-susceptible to ciprofloxacin and susceptible to other antimicrobial agents. None of non-toxigenic MDR isolates were found;
^b: F: Fisher's exact test; N/A: data not applicable;
^c: Non-toxigenic (A⁻B⁻) isolates were not included

ISSN: 1471-2334