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Table 2 Correlations among MLST types, toxin genotypes, and antimicrobial susceptibility patterns of the 186 C. difficile isolates

From: Molecular characteristics of Clostridium difficile in children with acute gastroenteritis from Zhejiang

Antimicrobial
agent
Total no. (%) of all the isolates (n = 186)MLST types (no. [%] of non-susceptible isolates)Analysis resultsbToxinotypesc (no. [%] of non-susceptible isolates)Analysis results
ST26 (n = 33)ST35 (n = 21)ST39 (n = 23)ST54 (n = 31)ST152 (n = 21)Other STsa (n = 57)χ2P valueA+B+ (n = 145)AB+ (n = 39)χ2P value
Clindamycin159 (85.5)33 (100.0)21 (100.0)18 (78.3)30 (96.8)13 (61.9)44 (77.2)F< 0.001125 (86.2)34 (87.2)0.020.875
Erythromycin160 (86.0)33 (100.0)21 (100.0)23 (100.0)30 (96.8)7 (33.3)46 (80.7)F< 0.001120 (82.8)39 (100.0)7.780.005
Fusidic acid129 (69.4)12 (36.4)15 (71.4)15 (65.2)28 (90.3)20 (95.2)39 (68.4)30.18< 0.001102 (70.3)27 (69.2)0.020.893
Rifampin7 (3.8)005 (21.7)01 (4.8)1 (1.8)F0.0012 (1.4)5 (12.8)8.090.004
Levofloxacin148 (79.6)19 (57.6)21 (100.0)16 (69.6)24 (77.4)21 (100.0)47 (82.5)F< 0.001117 (80.7)30 (76.9)0.270.602
Moxifloxacin14 (7.5)006 (26.1)01 (4.8)7 (12.3)F0.0013 (2.1)11 (28.2)29.26< 0.001
Gatifloxacin14 (7.5)006 (26.1)01 (4.8)7 (12.3)F0.0013 (2.1)11 (28.2)29.26< 0.001
Tetracycline17 (9.1)011 (52.4)01 (3.2)05 (8.8)F< 0.00113 (9.0)4 (10.3)0.060.805
Metronidazole0000000N/AN/A00N/AN/A
Vancomycin0000000N/AN/A00N/AN/A
PIP-TAZ0000000N/AN/A00N/AN/A
Ciprofloxacin184 (100.0)33 (100.0)21 (100.0)23 (100.0)31 (100.0)21 (100.0)57 (100.0)N/AN/A145 (100.0)39 (100.0)N/AN/A
MDR166 (89.2)33 (100.0)21 (100.0)21 (91.3)30 (96.8)15 (71.4)46 (80.7)F0.001129 (89.0)37 (94.9)0.640.425
  1. a: Of two non-toxigenic isolates, one (50.0%) was non-susceptible to erythromycin and levofloxacin; both of them (100.0%) were non-susceptible to ciprofloxacin and susceptible to other antimicrobial agents. None of non-toxigenic MDR isolates were found;
  2. b: F: Fisher's exact test; N/A: data not applicable;
  3. c: Non-toxigenic (AB) isolates were not included