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Table 4 “a” determinant Variants of Mother and their corresponding child’s HBV and Immunization status

From: Existence of hepatitis B virus surface protein mutations and other variants: demand for hepatitis B infection control in Cambodia

MotherChildNotes
Isolate IDAge classHBsAg/
Anti-HBs
Genotype/
sub-genotype
MutantIsolate IDAgeHBsAg/
Anti-HBs
Genotype/
sub-genotype
MutantHB-BD/
Penta
Reported Function
C174493m40–49+/−C1P127SC174492c5+/−C1P127S−/3Altered hydrophilicity, electrical charge and acidity of the loop
C171229m30–39+/−C1G145RC171228c5+/−C1−/3Vaccine Escapes Mutant
C17032930–39+/−B2/C2M133TC1703286−/++/3Rescue of virion secretion
C17103930–39+/−BM133TC1710386−/++/3Rescue of virion secretion
C17111820–29+/−CT131N, M133TC1711175−/−+/3Rescue of virion secretion,
Rescue of virion secretion
C17155020–29+/−C1G145AC1715496−/+−/3Vaccine Escapes Mutant
C17211620–29+/−C1P127AC1721156−/−+/1Unclear
C17307330–39+/−CI126NC1730725−/−+/3Vaccine Escapes Mutant
C17342920–29+/−CP127TC1734286−/+−/3Unclear
C17370630–39+/−CP127T, G145RC173055−/−+/3Unclear,
Vaccine Escapes Mutant
C17376420–29+/−C1F134LC1737635−/++/3Lower reactivity in HBsAg assay
C17386620–29+/−C1P127TC1738656−/+NA/3Unclear
C17433730–39+/+C1T131P, G145RC1743366−/++/3Unclear,
Vaccine Escapes Mutant
C17447820–29+/+C1T131IC1744776−/++/3Altered hydrophilicity, electrical charge and acidity of the loop
C17448320–29+/−CI126NC1744825−/−+/2Vaccine Escapes Mutant
C17426930–39+/+CI126NC1742685−/++/3Vaccine Escapes Mutant
C17046430–39+/−CT131NC1704635−/−+/3Rescue of virion secretion
  1. HB-BD: Birth dose Hepatitis B vaccine, Penta: Pentavalent vaccine including Hepatitis B Vaccine, HBsAg: Hepatitis B surface antigen, Anti-HBs: Hepatitis B surface antibody, M: Male, F: Female, NA: No information about immunization status, †: Full-length genome cannot be done, ‡: Immunization status was taken on recall memory of parents/guardians because no yellow book in hand during survey