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Table 4 “a” determinant Variants of Mother and their corresponding child’s HBV and Immunization status

From: Existence of hepatitis B virus surface protein mutations and other variants: demand for hepatitis B infection control in Cambodia

Mother

Child

Notes

Isolate ID

Age class

HBsAg/

Anti-HBs

Genotype/

sub-genotype

Mutant

Isolate ID

Age

HBsAg/

Anti-HBs

Genotype/

sub-genotype

Mutant

HB-BD/

Penta

Reported Function

C174493m

40–49

+/−

C1

P127S

C174492c

5

+/−

C1

P127S

−/3

Altered hydrophilicity, electrical charge and acidity of the loop

C171229m

30–39

+/−

C1

G145R

C171228c

5

+/−

C1

−/3

Vaccine Escapes Mutant

C170329

30–39

+/−

B2/C2

M133T

C170328

6

−/+

+/3

Rescue of virion secretion

C171039

30–39

+/−

B

M133T

C171038

6

−/+

+/3

Rescue of virion secretion

C171118

20–29

+/−

C

T131N, M133T

C171117

5

−/−

+/3

Rescue of virion secretion,

Rescue of virion secretion

C171550

20–29

+/−

C1

G145A

C171549

6

−/+

−/3

Vaccine Escapes Mutant

C172116

20–29

+/−

C1

P127A

C172115

6

−/−

+/1

Unclear

C173073

30–39

+/−

C

I126N

C173072

5

−/−

+/3

Vaccine Escapes Mutant

C173429

20–29

+/−

C

P127T

C173428

6

−/+

−/3

Unclear

C173706

30–39

+/−

C

P127T, G145R

C17305

5

−/−

+/3

Unclear,

Vaccine Escapes Mutant

C173764

20–29

+/−

C1

F134L

C173763

5

−/+

+/3

Lower reactivity in HBsAg assay

C173866

20–29

+/−

C1

P127T

C173865

6

−/+

NA/3

Unclear

C174337

30–39

+/+

C1

T131P, G145R

C174336

6

−/+

+/3

Unclear,

Vaccine Escapes Mutant

C174478

20–29

+/+

C1

T131I

C174477

6

−/+

+/3

Altered hydrophilicity, electrical charge and acidity of the loop

C174483

20–29

+/−

C

I126N

C174482

5

−/−

+/2

Vaccine Escapes Mutant

C174269

30–39

+/+

C

I126N

C174268

5

−/+

+/3

Vaccine Escapes Mutant

C170464

30–39

+/−

C

T131N

C170463

5

−/−

+/3

Rescue of virion secretion

  1. HB-BD: Birth dose Hepatitis B vaccine, Penta: Pentavalent vaccine including Hepatitis B Vaccine, HBsAg: Hepatitis B surface antigen, Anti-HBs: Hepatitis B surface antibody, M: Male, F: Female, NA: No information about immunization status, †: Full-length genome cannot be done, ‡: Immunization status was taken on recall memory of parents/guardians because no yellow book in hand during survey