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Table 4 Factor associated with inappropriate use of antibiotics

From: Inapropriate use of antibiotics effective against gram positive microorganisms despite restrictive antibiotic policies in ICUs: a prospective observational study

 

Inapropriate Use

N(%)

Appropriate Use

N(%)

P value

Age, mean ± SDa

64.3 ± 18.7

61.6 ± 20.8

.522

Genderb

 Female

78 (47)

16 (47.1)

.994

 Male

88 (53)

18 (52.9)

BMI (kg/m2), mean ± SDa

26.3 ± 6.24

27.0 ± 5.68

.228

CCI, mean ± SDa

4.51 ± 2.48

3.82 ± 2.35

.200

ICUb

 Medical

95 (57.2)

20 (58.8)

.864

 Surgical

71 (42.8)

14 (41.2)

Duration of Hospital Stay ± SDa (Day)

23.2 ± 27.0

20.9 ± 26.6

.439

Duration of ICU stay ± SDa (Day)

16.8 ± 25.8

16.5 ± 27.6

.591

Source of Infectionb

 Sepsis

70 (49.3)

9 (29)

.040

 Septic Schock

59 (30.5)

7 (20.6)

.091

 Pneumoniae

111 (66.9)

20 (58.8)

.369

 Blood Stream Infection (BSI)

46 (27.9)

5 (14.7)

.109

 Others

20 (12.0)

11 (32.4)

.003

 Unknown

32 (19.3)

3 (8.8)

.118

Antibiotic treatment approachb

 Emprical therapy

114 (68.7)

18 (52.9)

.078

 Agent spesific therapy

52 (31.3)

16 (47.1)

 Central Venous Catheter

109 (65.7)

16 (47.1)

.041

Laboratory Paremetersa

 WBC (×10.e3/μL), mean ± SD

14.672 ± 19.179

14.802 ± 10.087

.460

 PLT (×10.e3/μL), mean ± SD

221.879 ± 139.955

244.323 ± 156.829

.482

 Lactate (mMol/L), mean ± SD

2.06 ± 1.70

2.22 ± 1.91

.644

 GFR (mL/min), mean ± SD

50.6 ± 32.5

69.4 ± 26.8

.001

 Cr (mg/ dL), mean ± SD

1.93 ± 1.74

0.90 ± 0.79

<.001

 CRP (mg/L), mean ± SD

133 ± 92.8

156 ± 112

.041

 Procalcitonin (ng/ mL), mean ± SD

18.7 ± 85.5

14.9 ± 68.5

.013

  1. Abbreviations: SD standart deviation, BMI Body mass index, CCI Charslon comorbidity index, ICU Intensive care unit, WBC White blood cell, PLT Platelet, GFR Glomerular filtration rate, Cr Creatinine, CRP C-reactive protein
  2. aMann-Whitney U test was used
  3. bChi-squared test was used