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Table 4 Factor associated with inappropriate use of antibiotics

From: Inapropriate use of antibiotics effective against gram positive microorganisms despite restrictive antibiotic policies in ICUs: a prospective observational study

 Inapropriate Use
N(%)
Appropriate Use
N(%)
P value
Age, mean ± SDa64.3 ± 18.761.6 ± 20.8.522
Genderb
 Female78 (47)16 (47.1).994
 Male88 (53)18 (52.9)
BMI (kg/m2), mean ± SDa26.3 ± 6.2427.0 ± 5.68.228
CCI, mean ± SDa4.51 ± 2.483.82 ± 2.35.200
ICUb
 Medical95 (57.2)20 (58.8).864
 Surgical71 (42.8)14 (41.2)
Duration of Hospital Stay ± SDa (Day)23.2 ± 27.020.9 ± 26.6.439
Duration of ICU stay ± SDa (Day)16.8 ± 25.816.5 ± 27.6.591
Source of Infectionb
 Sepsis70 (49.3)9 (29).040
 Septic Schock59 (30.5)7 (20.6).091
 Pneumoniae111 (66.9)20 (58.8).369
 Blood Stream Infection (BSI)46 (27.9)5 (14.7).109
 Others20 (12.0)11 (32.4).003
 Unknown32 (19.3)3 (8.8).118
Antibiotic treatment approachb
 Emprical therapy114 (68.7)18 (52.9).078
 Agent spesific therapy52 (31.3)16 (47.1)
 Central Venous Catheter109 (65.7)16 (47.1).041
Laboratory Paremetersa
 WBC (×10.e3/μL), mean ± SD14.672 ± 19.17914.802 ± 10.087.460
 PLT (×10.e3/μL), mean ± SD221.879 ± 139.955244.323 ± 156.829.482
 Lactate (mMol/L), mean ± SD2.06 ± 1.702.22 ± 1.91.644
 GFR (mL/min), mean ± SD50.6 ± 32.569.4 ± 26.8.001
 Cr (mg/ dL), mean ± SD1.93 ± 1.740.90 ± 0.79<.001
 CRP (mg/L), mean ± SD133 ± 92.8156 ± 112.041
 Procalcitonin (ng/ mL), mean ± SD18.7 ± 85.514.9 ± 68.5.013
  1. Abbreviations: SD standart deviation, BMI Body mass index, CCI Charslon comorbidity index, ICU Intensive care unit, WBC White blood cell, PLT Platelet, GFR Glomerular filtration rate, Cr Creatinine, CRP C-reactive protein
  2. aMann-Whitney U test was used
  3. bChi-squared test was used