Skip to main content

Table 3 Comparison of clinical manifestations and laboratory tests with different EVs infected patients

From: Co-circulation of coxsackieviruses A-6, A-10, and A-16 causes hand, foot, and mouth disease in Guangzhou city, China

 TotalCVA-6CVA-10CVA-16
Clinical symptoms and signs
Total patientsN = 1220N = 364N = 305N = 397
 Cough304(24.9%)101(27.7%)65(21.3%)96(24.2%)
 Diarrhea60(4.9%)14(3.8%)14(4.6%)22(5.5%)
 Vomiting228(18.7%)60(16.5%)67(22.0%)79(19.9%)
 Fever spike (°C)39.3(39.0–39.8)39.4(39.0–39.8)39.5(39.0–39.9)39.0(38.9–39.9)
 Fever (> 38 °C)1093(89.6%)327(89.8%)280(91.8%)360(90.7%)
 Neurologic complications61(5.0%)20(5.5%)16(5.2%)6(1.5%)*
 Skin lesion1220(100%)364(100%)305(100%)397(100%)
 Mouth and/or pharyngeal1056(86.6%)300(82.4%)270(88.5%)340(85.7%)
 Hands and /or feet1117(91.6%)339(93.1%)264(86.6%)354(89.2%)
 Trunk210(17.2%)76(20.9%)51(16.7%)72(18.1%)
 Extremities1115(91.4%)342(94.0%)267(87.5%)362(91.2%)
Laboratory data
Total patientsN = 1220N = 364N = 305N = 397
 hsCRP(0-10 mg/L)6.93(2.50–17.08)9.67(3.68–22.84)14.26(3.92–27.3)4.23(2.50–8.90)*
 hsCRP (> 2.5 mg/L)868(71.1%)293(80.5%)*236(77.4%)246(62.0%)
 WBC(5-12 × 109/L)9.9(7.8–12.6)9.3(7.1–12.5)11.9(8.9–14.6)*9.48(7.8–11.3)
 WBC > 12 × 109/L362(29.7%)110(30.2%)146(47.9%)*74(18.6%)
 Neutrophils (3-10 × 109/L)5.3(3.4–8.0)4.3(2.7–8.1)7.1(4.5–10.1)*4.9(3.7–6.5)
 Neutrophils(> 10 × 109/L)167(13.7%)53(14.6%)80(26.2%)*20(5.0%)
 Lymphocyte (1.1–3.2 × 109/L)3.1(2.3–4.1)3.2(2.4–4.3)3.0(2.2–3.9)3.2(2.4–4.2)
 Lymphocyte(> 3.2 × 109/L)563(46.1%)197(49.2%)126(41.3%)196(49.4%)
  PLT (150-400 × 109/L)274(231–329)274(232–334)273(229–339)278(227–324)
 PLT(> 400 × 109/L)109(8.9%)30(8.2%)26(8.5%)36(9.1%)
Total patientsN = 758N = 236N = 204N = 246
 AST (30-40 U/L)36(31–41)35(30–41)36(32–40)36(31–41)
 AST(> 40 U/L)183(24.1%)60(25.4%)45(22.1%)66(26.8%)
 CK (30-135 U/L)94(72–118)90(69–111)96(75–120)97(72–126)
 CK(> 135 U/L)126(16.6%)50(21.2%)36(17.6%)34(13.8%)
 CK-MB(0-25 U/L)20(16–25)21(16–25)19(15–24)22(16–25)
 CK-MB(> 25 U/L)169(22.3%)52(22.0%)43(21.1%)60(24.4%)
  1. Continuous data are presented as median (interquartile range) and categorical data are presented as n (%)
  2. * Significant different compare with other groups, P < 0.05