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Table 3 In vitro antifungal susceptibility of 1844 clinical isolates of Candida species as determined by the CLSI method

From: Molecular identification and antifungal susceptibility profile of yeast from vulvovaginal candidiasis

      Antifungal agents    
Candida species(n)   BUC CLO FLC ITC MIC TEC VRC
C. albicans, n = 1272 Range 0.015–32 0.015–32 0.06–128 0.015–32 0.015–32 0.015–32 0.015–8
GM 0.11 0.05 0.79 0.09 0.30 0.15 0.07
MIC90 1 0.25 4 1 4 2 0.5
R    7.7% 10.2%    6.2%
C. africana, n = 49 Range 0.015–2. 0.015–4 0.125–1 0.015–1 0.015-0.5 0.03–16 0.03–0.5
GM 0.04 0.04 0.25 0.04 0.04 0.07 0.04
MIC90 0.06 0.06 0.5 0.06 0.125 0.5 0.06
C. dubliniensis n = 1 Range 0.015 0.015 4 0.125 0.03 0.015 0.015
C. glabrata, n = 267 Range 0.015–16 0.015–16 0.125–128 0.015–32 0.015–32 0.015–32 0.015–32
GM 0.21 0.20 1.48 0.38 0.25 0.16 0.09
MIC90 1 1 8 4 2 1 0.25
R    3.4% 29.1%   
C. nivariensis, n = 9 Range 0.03–1 0.03–0.5 0.125–32 0.03–0.5 0.03–16 0.03–1 0.03–4
MIC50 0.03 0.06 2 0.5 0.03 0.03 0.06
MIC90 0.125 0.125 4 0.5 2 1 0.5
C. bracarensis, n = 2 Range 0.03–1 0.03–0.5 0.25–2 0.125–2 0.03–4 0.03–1 0.03–0.125
MIC50 0.03 0.03 0.25 0.125 0.03 0.03 0.03
MIC90 1 0.5 2 2 4 1 0.125
C. parapsilosis, n = 76 Range 0.03–4 0.015–1 0.125–4 0.03–4 0.03–4 0.015–32 0.015–2
GM 0.18 0.04 0.47 0.07 0.54 0.03 0.04
MIC90 1 0.06 1 0.25 2 0.03 0.06
R    0 3%    1%
C. metapsilosis, n = 20 Range 0.03–1 0.03–0.25 0.25–4 0.03–1 0.03–8 0.015–0.05 0.015–0.06
GM 0.16 0.04 0.79 0.08 0.48 0.04 0.03
MIC90 1 0.06 2 1 4 0.25 0.06
C. orthopsilosis, n = 6 Range 0.03–8 0.03–1 0.125–4 0.03–1 0.25–8 0.03–0.25 0.03–0.25
MIC50 0.5 0.06 1.0 0.25 1.0 0.03 0.06
MIC90 8 1 4 1 8 0.25 0.25
C. tropicalis, n = 61 Range 0.03–2 0.015–0.5 0.125–128 0.015–32 0.03–32 0.03–2 0.03–4
GM 0.15 0.05 0.66 0.07 0.70 0.08 0.05
MIC90 1 0.25 8 0.125 8 0.25 0.25
R    10.9% 5.6%    4.3%
C. krusei, n = 54 Range 0.06–16 0.015–0.5 0.25–64 0.015–4 0.03–16 0.03–4 0.03–1
GM 0.85 0.08 15.69 0.27 0.72 0.14 0.21
MIC90 4 0.5 64 1 8 1 0.5
R    12.5%    0
Saccharomyces cerevisiae, n = 12 Range 0.015–2 0.015–1 0.125–32 0.015–2 0.06–8 0.015–0.5 0.03–1
GM 0.1 0.09 1.2 0.20 0.54 0.11 0.09
MIC90 0.5 0.5 8 2 4 0.5 0.25
C. guilliermondii, n = 2 Range 0.06–4 0.03–4 0.5–16 0.125–16 1–16 0.03–0.25 0.06–1
MIC50 0.06 0.03 0.5 0.125 1 0.03 0.06
MIC90 4 4 16 16 16 0.25 1
R    0 50%    0
C. lusitaniae, n = 1 Range 0.03 0.03 0.125 0.03 0.03 0.03 0.03
C.Fabianii, n = 3 Range 0.03–0.25 0.03–0.06 0.5–1 0.03–0.25 0.125–1 0.03 0.03
MIC50 0.125 0.03 0.5 0.06 0.125 0.03 0.03
MIC90 0.25 0.06 1 0.25 1 0.03 0.03
Trichosporon asahii,n = 1 Range 0.03 0.03 0.25 0.03 0.06 0.03 0.03
Rhodotorula, n = 3 Range 0.03–0.5 0.03–1 4–128 0.03–8 0.25–8 0.03–0.5 0.03–1
MIC50 0.06 0.06 64 2 1 0.06 0.03
MIC90 0.5 1 128 8 8 0.5 1
Kodamaea ohmeri, n = 2 Range 0.125–0.5 0.03 0.25–2 0.125–0.25 0.25–0.5 0.03 0.03
MIC50 0.125 0.03 0.25 0.125 0.25 0.03 0.03
MIC90 0.5 0.03 2 0.25 0.5 0.03 0.03
Issatchenkia terricola,n = 2 Range 1–4 0.06–0.125 32–64 0.25–0.5 0.5 0.25 0.25
MIC50 1 0.06 32 0.25 0.5 0.25 0.25
MIC90 4 0.125 64 0.5 0.5 0.25 0.25
Torulaspora pretoriensis,n = 1 Range 0.25 0.03 8 0.5 0.5 0.125 0.125
ATCC90028a Range 0.015–0.5 0.015–0.5 0.125–2 0.015–4 0.008–0.015 0.015–32 0.015–8
GM 0.04 0.03 0.21 0.08 0.06 0.03 0.03
MIC90 0.125 0.03 0.5 0.25 0.015 0.03 0.03
Candida species(n) Antifungal agents
  AmB FLU NYS TEB AFG CFG MFG
C. albicans n = 1272 Range 0.015–32 0.03–128 0.03–32 0.03–256 0.008–0.5 0.008–0.5 0.008–0.5
GM 0.22 0.70 1.60 45.11 0.015 0.1 0.03
MIC90 0.5 4 8 256 0.03 0.25 0.25
R   3.3%    0 0 0
C. africana n = 49 Range 0.03–32 0.06–8 0.125–4 0.25–256 0.008–0.03 0.015–0.5 0.008–0.5
GM 0.08 0.68 0.5 17.31 0.01 0.06 0.02
MIC90 1 2 4 128 0.015 0.25 0.06
C. dubliniensis n = 1 Range 0.06 0.06 0.25 16 0.008 0.015 0.008
C. glabrata n = 267 Range 0.03–2 0.06–16 0.03–32 0.25–256 0.008–0.5 0.008–0.5 0.008–0.5
GM 0.29 0.18 3.39 26.62 0.03 0.11 0.05
MIC90 1 1 8 256 0.06 0.25 0.25
R   0    0 0 0
C. nivariensis n = 9 Range 0.06–2 0.125–4 0.5–4 1–256 0.015–0.06 0.08–0.5 0.015–0.5
MIC50 0.06 0.5 1 128 0.06 0.25 0.015
MIC90 2 2 4 256 0.06 0.5 0.5
C. bracarensis n = 2 Range 0.06–1 0.125–2 0.25–8 8–256 0.015–0.03 0.125–0.5 0.015–0.5
MIC50 0.06 0.125 0.25 8 0.015 0.125 0.015
MIC90 1 2 8 256 0.03 0.5 0.5
C. parapsilosis n = 76 Range 0.03–2 0.125–8 0.03–32 0.25–256 0.008–1 0.008–1 0.008–1
GM 0.19 0.14 0.59 0.62 0.69 0.60 0.54
MIC90 1 0.125 4 32 0.5 0.5 0.5
R   0    5.2% 5.2% 1.3%
C. metapsilosis n = 20 Range 0.015–0.5 0.125–4 0.06–4 0.25–256 0.015–0.5 0.008–0.5 0.015–1
GM 0.10 0.177 0.46 2.17 0.17 0.17 0.39
MIC90 0.5 1 4 256 0.25 0.25 0.5
C. orthopsilosis n = 6 Range 0.06–0.25 0.125–2 0.06–8 0.25–128 0.008–1 0.015–1 0.008–0.5
MIC50 0.125 1 0.5 64 0.008 0.03 0.25
MIC90 0.25 2 8 128 1 1 0.5
C. tropicalis n = 61 Range 0.03–1 0.125–32 0.03–8 0.25–256 0.015–0.125 0.008–0.5 0.008–0.5
GM 0.19 0.23 0.54 60.02 0.03 0.24 0.04
MIC90 0.5 1 4 256 0.06 0.5 0.5
R   1.8%    0 0 0
C. krusei n = 54 Range 0.03–1 0.125–32 0.03–4 16–256 0.015–0.5 0.008–1 0.008–0.5
GM 0.43 4.2 0.32 75.66 0.08 0.08 0.15
MIC90 1 16 1 256 0.125 0.5 0.25
R   2.9%    0 1.85% 0
Saccharomyces cerevisiae n = 12 Range 0.03–4 0.06–8 0.125–32 0.25–256 0.015–0.5 0.008–0.5 0.015–0.5
GM 0.18 0.21 0.78 53.20 0.14 0.10 0.18
MIC90 1 1 8 256 0.5 0.25 0.25
C. guilliermondii n = 2 Range 0.06–0.5 0.125–0.25 0.25–0.5 64–128 0.015–0.25 0.25–0.5 0.015–0.25
MIC50 0.06 0.125 0.25 64 0.015 0.25 0.015
MIC90 0.5 0.25 0.5 128 0.25 0.5 0.25
R   0    0 0 0
C. lusitaniae n = 1 Range 0.125 0.125 0.25 0.25 0.03 0.25 0.015
C. fabianii n = 3 Range 0.06–0.25 0.125 0.25 128 0.015–0.03 0.015–0.25 0.015–0.06
MIC50 0.06 0.125 0.25 128 0.015 0.015 0.03
MIC90 0.25 0.125 0.25 128 0.03 0.25 0.06
Trichosporon asahii n = 1 Range 0.125 1 0.25 128 0.015 0.5 0.015
Rhodotorula n = 3 Range 0.03–0.5 0.125 0.06–0.125 8–256 0.06–0.5 0.25–0.5 0.25–0.5
MIC50 0.03 0.125 0.06 8 0.06 0.25 0.25
MIC90 0.5 0.125 0.125 256 0.5 0.5 0.5
Kodamaea ohmeri n = 2 Range 0.125–1 0.125 0.5 128 0.015 0.125–0.25 0.015–0.03
MIC50 0.125 0.125 0.5 128 0.015 0.125 0.015
MIC90 1 0.125 0.5 128 0.015 0.25 0.03
Issatchenkia terricola n = 2 Range 0.125–0.5 8 0.5 128–256 0.06 0.06 0.008
MIC50 0.125 8 0.5 128 0.06 0.06 0.008
MIC90 0.5 8 0.5 256 0.06 0.06 0.008
Torulaspora pretoriensis n = 1 Range 0.125 0.125 0.25 16 0.015 0.125 0.015
ATCC90028a Range 0.03–2 0.125–8 0.25–16 1–256 0.008–0.015 0.015–0.5 0.008–0.015
  GM 0.22 0.64 1.31 88.22 0.01 0.09 0.01
  MIC90 1 2 8 256 0.015 0.5 0.015
  1. Note: GM geometry mean, BUC butoconazole, CLO Clotrimazole, FLC Fluconazole, ITC Itraconazole, VRC Voriconazole, MIC Miconazole, TEC Terconazole, AmB Amphotericin B, FLU Flucytosine, NYS Nystatin, TEB Terbinafine, AFG Anidulafungin, CFG Caspofungin, MFG Micafungin
  2. a ATCC90028 was tested 57 times