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Table 2 Correlations between main classes of antibiotics consumption intensity and the rate of fluoroquinolone-resistant gram-negative bacteria

From: Association between the rate of fluoroquinolones-resistant gram-negative bacteria and antibiotic consumption from China based on 145 tertiary hospitals data in 2014

Classes (ATC category)

Correlation

fluoroquinolone-resistant E. coli

n = 138

fluoroquinolone-resistant K. pneumoniae

n = 139

fluoroquinolone-resistant P. aeruginosa

n = 139

Levofloxacin-resistant A. baumannii

n = 131

Ciprofloxacin-resistant A. baumannii

n = 133

ra

p*

r

p

r

p

r

p

r

p

All antibiotics(J01)

0.174

0.062

0.247*

0.003

0.260*

0.002

0.282*

0.001

0.194

0.055

Beta-lactams(J01C + J01D)

−0.035

0.682

0.116

0.173

0.109

0.202

0.165

0.060

0.165

0.058

Beta-lactam-beta-lactamase inhibitor combinations

−0.176

0.093

0.135

0.113

−0.046

0.589

−0.039

0.656

0.037

0.671

Beta-lactams excluding CBLI

0.118

0.167

0.088

0.303

0.152

0.075

0.200

0.072

0.154

0.077

Penicillins(J01C)

−0.118

0.169

0.040

0.643

0.126

0.140

0.081

0.359

0.036

0.678

Penicillins excluding CBLI

0.004

0.964

0.046

0.590

0.212

0.072

0.215

0.064

0.078

0.371

Cephalosporins(J01DB + J01DC + J01DD + J01DE)

−0.014

0.873

0.068

0.426

0.061

0.478

0.157

0.074

0.185

0.053

Cephalosporins excluding CBLI

0.095

0.269

0.034

0.693

0.091

0.286

0.139

0.112

0.141

0.106

3-GC(J01DD)

−0.055

0.524

0.147

0.085

0.063

0.459

0.194

0.067

0.156

0.073

3GC excluding CBLI

0.093

0.276

0.131

0.125

0.109

0.203

0.246*

0.005

0.133

0.127

4-GC(J01DE)

0.037

0.671

−0.063

0.460

0.044

0.611

−0.182

0.077

−0.028

0.748

Carbapenems(J01DH)

0.129

0.131

0.242*

0.004

−0.065

0.445

−0.003

0.975

0.002

0.983

Fluoroquinolones(J01MA)

0.308**

0.000

0.291*

0.001

0.319*

0.000

0.254*

0.003

0.159

0.068

Ciprofloxacin (J01MA02)

−0.014

0.869

0.075

0.383

0.054

0.532

−0.021

0.811

0.077

0.376

Levofloxacin (J01MA12)

0.252*

0.003

0.260*

0.002

0.377*

0.000

0.336*

0.000

0.157

0.072

Moxifloxacin (J01MA14)

0.131

0.127

0.093

0.278

−0.200

0.088

−0.192

0.081

−0.014

0.875

  1. ATC Anatomic Therapeutic Chemical; CBLI combinations with beta-lactamase inhibitors; 3-GC the third generation cephalosporins; 4-GC the fourth generation cephalosporins.