Variables | Longitudinal Process | Multi-State Process | |||||
---|---|---|---|---|---|---|---|
β (95% CI) | Transition 1: Normal to Mild, β (95% CI) | Transition 2: Mild to Advanced, β (95% CI) | Transition 3: Advanced to Severe, β (95% CI) | Transition 4: Severe to Advanced, β(95% CI) | Transition 5: Advanced to Mild, β (95% CI) | Transition 6: Mild to Normal, β (95% CI) | |
Intercepts | 2.197 (2.016, 2.377)*** | 1.41 (0.53, 2.28)* | 1.21 (0.52, 1.91)* | 2.08 (0.71, 3.46)* | 2.46 (0.13, 4.79)* | − 0.01 (− 0.84, 0.83) | 1.71 (0.79, 2.62)* |
TB: Yes | 0.147 (0.045, 0.249)** | 0.61 (− 0.14, 1.37) | 0.15 (− 0.43, 0.74) | 1.50 (− 0.39, 3.39) | 0.41 (− 2.42, 3.23) | − 0.47 (− 1.06, 0.12) | 0.98 (− 0.24, 1.72) |
Marital status: Married (stable sex partner) | − 0.119 (− 0.170, − 0.068)* | 0.44 (− 0.15, 1.03) | − 0.58 (− 1.17, 0.01) | −1.11 (− 2.15, − 0.06)* | −0.13 (− 1.50, 1.24) | −0.09 (− 0.64, 0.46) | 0.05 (− 0.54, 0.64) |
Marital status: Many sexual partners | − 0.020 (− 0.117, 0.078) | −0.07 (− 0.40, 0.27) | 0.001 (− 0.99, 1.00) | − 0.50 (− 1.23, 0.22) | −0.61 (− 0.94, − 0.28)* | −0.09 (− 0.47, 0.30) | − 0.02 (− 0.36, 0.32) |
Education: 9–10th Grade | − 0.053 (− 0.132, 0.027) | −0.90 (− 1.34, 0.46) | −0.26 (− 0.67, 0.15) | −0.32 (− 1.13, 0.49) | 1.02 (− 0.10, 2.15) | 0.34 (− 0.13, 0.81) | 0.28 (− 0.21, 0.77) |
Education: ≥ 11th Grade | −0.136(− 0.207, − 0.064)** | −1.20 (− 1.66, − 0.74)* | 0.03 (− 0.42, 0.48) | 0.80 (− 0.06, 1.66) | 0.71 (0.50, 1.91)* | 0.19 (− 0.31, 0.68) | 0.59 (0.15, 1.03)* |
Age_Cat: < 20 years | 0.018(− 0.039, 0.075) | 0.36 (0.01, 0.70)** | 0.34 (− 0.03, 0.70) | 0.15 (− 0.61, 0.92) | 0.55 (− 0.44, 1.53) | 0.22 (− 0.18, 0.62) | 0.17 (− 0.15, 0.48) |
Age_Cat: 21–39 years | − 0.119(− 0.229, − 0.009)* | 0.08 (− 0.47, 0.63) | 0.11 (− 0.58, 0.79) | −1.36 (− 3.17, 0.45) | 1.23 (− 0.58, 3.04) | 1.09 (0.32, 1.85)*** | 1.01 (0.48, 1.53)** |
Sex while drunk: No | −0.060(− 0.134, 0.015) | 0.10 (− 0.31, 0.51) | −0.23 (− 0.67, 0.20) | −0.55 (− 1.29, 0.18) | 1.23 (0.28, 2.17)* | − 0.17 (− 0.58, 0.23) | 0.17 (− 0.26, 0.59) |
Weight | −0.037(− 0.057, − 0.018)** | − 0.23 (− 0.33, − 0.12)* | −0.30 (− 0.42, − 0.17)* | 0.03 (− 0.27, 0.33) | 0.21 (− 0.24, 0.65) | − 0.03 (− 0.19, 0.13) | −0.03 (− 0.12, 0.07) |
Level of independence score | − 0.006(− 0.017, 0.005) | − 0.48 (− 0.60, − 0.37)* | −0.11 (− 0.23, 0.01)* | −0.37 (− 0.65, − 0.09)* | −0.05 (− 0.35, 0.26) | −0.03 (− 0.16, 0.09) | 0.14 (0.03, 0.26)* |
Social relationship score | −0.015(− 0.026, − 0.003)* | −0.12 (− 0.24, 0.01) | −0.04 (− 0.16, 0.08) | −0.25 (− 0.49, 0.01) | −0.14 (− 0.44, 0.17) | 0.001 (− 0.13, 0.14) | −0.26 (− 0.38, 0.14) |
Physical health score | − 0.014(− 0.027, − 0.001)* | − 0.45 (− 0.64, − 0.27)* | −0.36 (− 0.54, − 0.17)* | −0.25 (− 0.61, − 0.11)* | −0.49 (− 0.93, 0.06) | −0.36 (− 0.53, 0.19) | −0.36 (− 0.52, 0.20) |
Psychological well-bing score | 0.005(− 0.008, 0.018) | 0.51 (0.32, 0.70) | 0.14 (− 0.04, 0.32) | 0.13 (− 0.19, 0.45) | 0.50 (0.11, 0.90)** | 0.07 (− 0.10, 0.23) | 0.37 (0.19, 0.55)* |
Liver enzymes abnormality component | 0.006(−0.002, 0.013) | − 0.08 (− 0.18, 0.03) | −0.04 (− 0.15, 0.08) | 0.04 (− 0.15, 0.22) | 0.11 (− 0.16, 0.38) | −0.17 (− 0.30, − 0.05)* | 0.04 (− 0.07, 0.16) |
RBC indices | −0.009(− 0.017, − 0.002)* | −0.03 (− 0.13, 0.07) | −0.19 (− 0.30, − 0.07)* | 0.04 (− 0.19, 0.26) | −0.07 (− 0.35, 0.21) | −0.08 (− 0.21, 0.04) | 0.16 (0.04, 0.27)* |
Granulocytes component | −0.002(− 0.009, 0.006) | −0.08 (− 0.18, 0.02) | −0.13 (− 0.25, − 0.02)* | −0.05 (− 0.28, 0.18) | 0.001 (− 0.31, 0.32) | 0.12 (0.001, 0.25)* | 0.12 (0.01, 0.23)* |
Mononuclear component | 0.017(−0.009, 0.024) | − 0.35 (− 0.48, − 0.23)* | −0.45 (− 0.58, − 0.33)* | −0.56 (− 0.84, − 0.28)* | 0.03 (− 0.23, 0.28) | 0.33 (0.22, 0.45)*** | 0.32 (0.21, 0.43)* |
Time Slope | Associations between Transitions and Longitudinal Outcomes | ||||||
Visit | −0.007(− 0.015, 0.001) | Transitions based on CD4 count Vs Viral Load | Coefficient | 95% CI of β | P-value |  |  |
Weight | 0.001(−0.001, 0.001) | Trans 1 vs baseline VL | 0.51 | (−0.35, 1.37) | 0.054 |  |  |
Psychological well-bing score | 0.001(−0.001, 0.002) | Trans 2 vs baseline VL | −0.33 | (−0.66, − 0.001) | 0.043* |  |  |
Physical health score | −0.004(− 0.008, − 0.001)* | Trans 3 vs baseline VL | 0.18 | (− 0.11, 0.47) | 0.227 |  |  |
Level of independence score | 0.001(−0.001, 0.001) | Trans 4 vs baseline VL | 0.56 | (0.24, 0.88) | 0.001** |  |  |
Social relationship score | 0.001(−0.001, 0.002) | Trans 5 vs baseline VL | 1.14 | (0.75, 1.54) | 0.000*** |  |  |
Marital Status: Married (stable sex partner) | 0.005(−0.003, 0.007) | Trans 6 vs baseline VL | 2.21 | (1.20, 3.21) | 0.000** |  |  |
Marital Status: many sex partners | 0.007 (0.003, 0.011)* | Trans 1 vs Time slope VL | 0.06 | (−0.93, 1.05) | 0.909 |  |  |
RBC indices | −0.01(− 0.09, − 0.002)* | Trans 2 vs Time slope VL | −0.32 | (− 1.30, 0.67) | 0.528 |  |  |
TB: Yes | 0.002 (0.001, 0.004)* | Trans 3 vs Time slope VL | 0.62 | (−1.92, 3.16) | 0.632 |  |  |
Sex while drunk: No | 0.0001(−0.003, 0.003) | Trans 4 vs Time slope VL | 3.34 | (0.26, 6.42) | 0.034* |  |  |
Age_Cat:< 20 | 0.008 (0.003, 0.012)* | Trans 5 vs Time slope VL | 2.15 | (0.69, 3.61) | 0.004** |  |  |
Age_Cat: 21–39 years | 0.001(−0.001, 0.003) | Trans 6 vs Time slope VL | 1.22 | (0.05, 2.40) | 0.042* |  |  |
Education: 9–10th Grade | 0.001(−0.002, 0.004) |  |  |  |  |  |  |
Education: ≥ 11th Grade | −0.001(−0.004, − 0.0003)* |  |  |  |  |  |  |
Liver enzymes abnormality component | 0.004 (0.001, 0.01)* | Â | Â | Â | Â | Â | Â |