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Table 3 Diagnostic accuracy of Ultra on FNA and tissue measured against the composite reference standard and culture

From: Diagnostic accuracy of the Xpert MTB/Rif Ultra for tuberculosis adenitis

 SensitivitySpecificityPPVNPVLR+LR-
Composite reference standard
 Ultra on FNA (n = 73 participants)21/30; 70% (51–85)43/43; 100% (92–100)100%83%inv0.3
 Ultra on tissue (n = 81 participants)16/24; 67% (45–84)55/57; 96% (88–99)89%87%16.80.3
Excluding the 21 participants on tuberculosis therapy>24 h
 Ultra on FNA (n = 57 participants)12/20; 60% (36–81)37/37; 100% (91–100)100%82%inv0.4
 Ultra on tissue (n = 66 participants)10/18; 56% (31–78)46/48; 96% (86–99)83%85%140.5
Culture as the reference standard (n = 99 participants)
 Ultra on FNA (n = 73 participants)7/9; 78% (40–97)50/64; 78% (66–87)33%96%3.50.3
 Ultra on tissue (n = 81 participants)9/10; 90% (55–100)62/71; 87% (77–94)50%98%6.90.1
  1. Data are n/N; % (95% CI). FNA Fine-needle aspirate, AFBs Acid fast bacilli, PPV Positive predictive value, NPV Negative predictive value, LR likelihood ratio