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Table 2 Model calibration: Parameter variation range, calibration formulae and results

From: A hybrid simulation model approach to examine bacterial genome sequencing during a hospital outbreak

ParameterParameter calibration rangecOptimal calibration resultsCalibration #2 resultsCalibration #3 results
Level 2 Beta valuea0.001–0.20.140.0940.139
Level 5 Beta valuea0.001–0.20.1530.1640.185
SIU Beta valuea0.001–0.20.0860.0680.08
GARU Beta valuea0.001–0.20.0860.0740.089
Lvl5 microbial test prob.b0.01–0.070.0410.0550.04
Lvl2 microbial test prob.b0.01–0.070.0430.0470.045
SIU microbial test prob.b0.01–0.070.0560.0410.041
GARU microbial test prob.b0.01–0.070.0550.0460.059
RNG 1 Seed1–1000701457952
RNG 2 Seed1–1000382697129
RNG 3 Seed1–1000465810348
Detected colonizationsActual outbreakOptimal calibrationCalibration #2Calibration #3
Day 69:
Lvl5, Lvl2, GARU, SIU
6, 1, 1, 17, 3, 0, 18, 0, 0, 110, 1, 1, 1
Day 83:
Lvl5, Lvl2, GARU, SIU
11, 3, 1, 410, 6, 0, 116, 0, 1, 312, 1, 2, 1
Day 111:
Lvl5, Lvl2, GARU, SIU
25, 13, 14, 821, 10, 5, 823, 0, 11, 619, 4, 12, 1
Total72757573
Calibration Formulaedabs (Lvl5 day69-AO Lvl5 day69) + abs (Lvl5 day83-AO Lvl5 day83) + abs (Lvl5 day111-AO Lvl5 day111) + abs (Lvl2 day69-AO Lvl2 day69) + abs (Lvl2 day83-AO Lvl2 day83) + abs (Lvl2 day111-AO Lvl2 day111) + abs (GARU day69-AO GARU day69) + abs (GARU day83-AO GARU day83) + abs(GARU day111-AO GARU day111) + abs(SIU day69-AO SIU day69) + abs(SIU day83-AO SIU day83) + abs(SIU day111-AO SIU day111) + abs(Total-AO Total)
  1. Lvl5 Level five, Lvl2 Level two, GARU Geriatric and Rehabilitation Unit, SIU Spinal injury unit, AO Actual outbreak, RNG random number generator, abs absolute value, prob Probability
  2. aBeta value used in transmission formulae, \( 1-\exp \left\{\frac{-\beta C}{N}\right\} \)
  3. bThe daily probability a patient in that floor will be randomly screened
  4. cThe values tested across 50,000 simulations
  5. dDays 69 and 83 were chosen due spikes in colonization detections and day 111 was when the last detection occurred