Table 2 Treatment outcomes and associated factors among adult persons with complete SVR data receiving SOF-based regimens within the national hepatitis C elimination program, April 28, 2015 – October 31, 2018
Total N | Achieved SVR | Bivariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|---|
N | % | RR | 95% CI | p value | RR | 95% CI | p value | ||
Age category | |||||||||
18–45 | 1635 | 1440 | 88.07 | 1 | |||||
46–60 | 2838 | 2259 | 79.60 | 0.90 | 0.88–0.93 | <0.0001 | |||
60+ | 606 | 471 | 77.72 | 0.88 | 0.84–0.92 | <0.0001 | |||
Gender | |||||||||
Female | 698 | 560 | 80.23 | 1 | |||||
Male | 4381 | 3610 | 82.40 | 1.03 | 0.99–1.07 | 0.18 | |||
HCV Genotype | |||||||||
1 | 1724 | 1198 | 69.49 | 1 | 1 | ||||
2 | 1047 | 852 | 81.38 | 1.17 | 1.12–1.22 | <0.0001 | 1.10 | 1.05–1.15 | <0.0001 |
3 | 2305 | 2117 | 91.84 | 1.32 | 1.28–1.37 | <0.0001 | 1.14 | 1.11–1.18 | <0.0001 |
4 | 3 | 3 | 100.00 | – | – | – | – | – | – |
HCV RNA categories, n (%) | |||||||||
< 800,000 IU/mL | 2922 | 2408 | 82.41 | 1 | |||||
≥ 800,000 IU/mL | 2145 | 1754 | 81.77 | 0.99 | 0.97–1.02 | 0.56 | |||
FIB-4 Tests | |||||||||
< 1.45 | 200 | 177 | 88.50 | 1 | 1 | ||||
1.45–3.25 | 1763 | 1573 | 89.22 | 1.01 | 0.96–1.06 | 0.76 | 1.00 | 0.93–1.07 | 0.95 |
> 3.25 | 1546 | 1166 | 75.42 | 0.85 | 0.80–0.90 | <0.0001 | 0.95 | 0.87–1.02 | 0.17 |
Metavir score | |||||||||
< F4 | 2021 | 1761 | 87.14 | 1 | 1 | ||||
F4 | 2783 | 2161 | 77.65 | 0.89 | 0.87–0.97 | <0.0001 | 0.95 | 0.93–0.98 | 0.0001 |
Co-infections | |||||||||
HBsAg- | 4777 | 3897 | 81.58 | 1 | |||||
HBsAg+ | 108 | 89 | 82.41 | 1.01 | 0.92–1.10 | 0.82 | |||
Treatment regimen | |||||||||
IFN/SOF/RBV (12 wk) | 2646 | 2416 | 91.31 | 1 | 1 | ||||
SOF/RBV (12 wk) | 364 | 276 | 75.82 | 0.83 | 0.78–0.88 | <0.0001 | 0.85 | 0.81–0.91 | <0.0001 |
SOF/RBV (20 wk) | 395 | 302 | 76.46 | 0.84 | 0.79–0.89 | <0.0001 | 0.86 | 0.82–0.92 | <0.0001 |
SOF/RBV (24 wk) | 1418 | 979 | 69.04 | 0.76 | 0.73–0.78 | <0.0001 | 0.88 | 0.85–0.91 | <0.0001 |
SOF/RBV (48 wk) | 256 | 197 | 76.95 | 0.84 | 0.79–0.90 | <0.0001 | 0.92 | 0.87–0.98 | 0.005 |
City of treatment site | |||||||||
Tbilisi | 3800 | 3127 | 82.29 | 1 | 1 | ||||
Kutaisi | 362 | 272 | 75.14 | 0.91 | 0.86–0.97 | 0.004 | 0.96 | 0.92–1.01 | 0.10 |
Batumi | 501 | 435 | 86.83 | 1.06 | 1.02–1.10 | 0.005 | 1.01 | 0.97–1.05 | 0.60 |
Zugdidi | 328 | 258 | 78.66 | 0.96 | 0.90–1.01 | 0.13 | 0.96 | 0.92–1.00 | 0.07 |
Gori | 42 | 40 | 95.24 | 1.16 | 1.08–1.24 | <0.0001 | 1.01 | 0.87–1.17 | 0.91 |
Rustavi | 40 | 32 | 80.00 | 0.97 | 0.83–1.14 | 0.72 | 0.95 | 0.80–1.13 | 0.55 |
Lanchkhuti | 4 | 4 | 100.00 | – | – | – | – | – | – |
Gurjaani | 2 | 2 | 100.00 | – | – | – | – | – | – |