Bioinformatics analysis on multiple Gene Expression Omnibus datasets of the hepatitis B virus infection and its response to the interferon-alpha therapy

Table 4 Top 10 genes in gene signal network in 3 cohorts

Rank	Gene symbol	Gene description	Degree
Cohort 1
1	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	56
2	TYMS	thymidylate synthetase	30
3	PLA2G2A	phospholipase A2, group IIA	28
4	PLD3	phospholipase D family, member 3	24
5	PPAP2B	phosphatidic acid phosphatase type 2B	22
6	CDKN1A	cyclin-dependent kinase inhibitor 1A	8
7	CCR2	chemokine (C-C motif) receptor 2	7
8	CXCR4	chemokine (C-X-C motif) receptor 4	7
9	AKT1	v-akt murine thymoma viral oncogene homolog 1	5
10	CCL5	chemokine (C-C motif) ligand 5	4
Cohort 2
1	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	56
2	TYMS	thymidylate synthetase	30
3	ACTB	actin, beta	28
4	ACTN4	actinin, alpha 4	24
5	PLA2G2A	phospholipase A2, group IIA	22
6	PLD3	phospholipase D family, member 3	16
7	PPAP2B	phosphatidic acid phosphatase type 2B	10
8	CDKN1A	cyclin-dependent kinase inhibitor 1A	8
9	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	7
10	CCR2	chemokine (C-C motif) receptor 2	6.5
Cohort 3
1	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	18
2	EP300	E1A binding protein p300	18
3	ADCY1	adenylate cyclase 1	18
4	CREB1	cAMP responsive element binding protein 1	17
5	STAT1	signal transducer and activator of transcription 1	15
6	CTNNB1	catenin (cadherin-associated protein), beta 1, 88 kDa	15
7	ITGB5	integrin, beta 5	15
8	PRKCB	protein kinase C, beta	14
9	STAT3	signal transducer and activator of transcription 3	12
10	AKT2	v-akt murine thymoma viral oncogene homolog 2	10

ISSN: 1471-2334