Skip to main content

Table 4 Top 10 genes in gene signal network in 3 cohorts

From: Bioinformatics analysis on multiple Gene Expression Omnibus datasets of the hepatitis B virus infection and its response to the interferon-alpha therapy

Rank Gene symbol Gene description Degree
Cohort 1
 1 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 56
 2 TYMS thymidylate synthetase 30
 3 PLA2G2A phospholipase A2, group IIA 28
 4 PLD3 phospholipase D family, member 3 24
 5 PPAP2B phosphatidic acid phosphatase type 2B 22
 6 CDKN1A cyclin-dependent kinase inhibitor 1A 8
 7 CCR2 chemokine (C-C motif) receptor 2 7
 8 CXCR4 chemokine (C-X-C motif) receptor 4 7
 9 AKT1 v-akt murine thymoma viral oncogene homolog 1 5
 10 CCL5 chemokine (C-C motif) ligand 5 4
Cohort 2
 1 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 56
 2 TYMS thymidylate synthetase 30
 3 ACTB actin, beta 28
 4 ACTN4 actinin, alpha 4 24
 5 PLA2G2A phospholipase A2, group IIA 22
 6 PLD3 phospholipase D family, member 3 16
 7 PPAP2B phosphatidic acid phosphatase type 2B 10
 8 CDKN1A cyclin-dependent kinase inhibitor 1A 8
 9 PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 7
 10 CCR2 chemokine (C-C motif) receptor 2 6.5
Cohort 3
 1 PRKACB protein kinase, cAMP-dependent, catalytic, beta 18
 2 EP300 E1A binding protein p300 18
 3 ADCY1 adenylate cyclase 1 18
 4 CREB1 cAMP responsive element binding protein 1 17
 5 STAT1 signal transducer and activator of transcription 1 15
 6 CTNNB1 catenin (cadherin-associated protein), beta 1, 88 kDa 15
 7 ITGB5 integrin, beta 5 15
 8 PRKCB protein kinase C, beta 14
 9 STAT3 signal transducer and activator of transcription 3 12
 10 AKT2 v-akt murine thymoma viral oncogene homolog 2 10