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Table 2 Patterns of BCP/pre-core mutants in two groups of acute hepatitis B patients from North-East Italy occurred 16 years apart

From: Retrospective analysis of acute HBV infections occurred in 1978–79 and 1994–95 in North-East Italy: increasing prevalence of BCP/pre-core mutants in sub-genotype D3

 1978–791994-95
TotalHBeAg(-)HBV-D3TotalHBeAg(-)HBV-D3
Number of patients501625a301313a
BCP/pre-core mutation pattern (n° of patients):
 G1764A   413
 G1896A311221
 T1753C/A, G1896A   11 
 A1762T, G1764A1  1  
 G1896A, G1899A1 111 
 T1753C/A, A1762T, G1764A, G1896A   111
 T1753C/A, A1762T, G1764A, G1899A11    
 T1753C/A, A1762T, G1764A, G1896A, G1899A   221
 Patients with at least one BCP/pre-core mutation (n°,%)6 (12.0%)#2 (12.5%)§2 (8.0%)^12 (40.0%)#8 (61.5%)§6 (46.0%)^
  1. adue to sample volume limitations, only a subset of HBV-D cases could be sub-genotyped by analysis of S region: 29/43 from the 1978–79 group and 16/24 from the 1994–95 group. Sub-genotype D3 was by far the most abundant in both groups, with 25 and 13 cases, respectively
  2. # p = 0.006 (Fisher’s exact test); all cases with BCP/pre-core mutations were HBV-D
  3. § p = 0.016 (Fisher’s exact test)
  4. ^ p = 0.011 (Fisher’s exact test)