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Table 2 Patterns of BCP/pre-core mutants in two groups of acute hepatitis B patients from North-East Italy occurred 16 years apart

From: Retrospective analysis of acute HBV infections occurred in 1978–79 and 1994–95 in North-East Italy: increasing prevalence of BCP/pre-core mutants in sub-genotype D3

 

1978–79

1994-95

Total

HBeAg(-)

HBV-D3

Total

HBeAg(-)

HBV-D3

Number of patients

50

16

25a

30

13

13a

BCP/pre-core mutation pattern (n° of patients):

 G1764A

   

4

1

3

 G1896A

3

1

1

2

2

1

 T1753C/A, G1896A

   

1

1

 

 A1762T, G1764A

1

  

1

  

 G1896A, G1899A

1

 

1

1

1

 

 T1753C/A, A1762T, G1764A, G1896A

   

1

1

1

 T1753C/A, A1762T, G1764A, G1899A

1

1

    

 T1753C/A, A1762T, G1764A, G1896A, G1899A

   

2

2

1

 Patients with at least one BCP/pre-core mutation (n°,%)

6 (12.0%)#

2 (12.5%)§

2 (8.0%)^

12 (40.0%)#

8 (61.5%)§

6 (46.0%)^

  1. adue to sample volume limitations, only a subset of HBV-D cases could be sub-genotyped by analysis of S region: 29/43 from the 1978–79 group and 16/24 from the 1994–95 group. Sub-genotype D3 was by far the most abundant in both groups, with 25 and 13 cases, respectively
  2. # p = 0.006 (Fisher’s exact test); all cases with BCP/pre-core mutations were HBV-D
  3. § p = 0.016 (Fisher’s exact test)
  4. ^ p = 0.011 (Fisher’s exact test)