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Table 1 Demographic, clinical and virological characteristics at hospital admission of 80 HBsAg/anti-HBc IgM positive patients in 1978–79 and 1994–95 surveys of acute hepatitis B in North-East Italy

From: Retrospective analysis of acute HBV infections occurred in 1978–79 and 1994–95 in North-East Italy: increasing prevalence of BCP/pre-core mutants in sub-genotype D3

Years1978–791994–95
Number of patients5030
Sex M/F (index)28/22 (1.3)18/13 (1.4)
Median age (range)32 (23–85)25 (15–78)
HBeAg positive (%)34 (68.0)17 (56.7)
HBeAg negative (%)16 (32.0)13 (43.3)
Anti-HBe positive (%)29 (58.0)17 (56.7)
Mean Log10 HBV DNA (range)5.51 (3.29–8.51)4.34 (1.48–8.71)
Anti-HDV positive (%)2 (4.0)3 (10.0)
Anti-HCV positive (%)12 (24.0)8 (25.8)
Mean hospital days (range)37.6 (18–77)19.5 (8–26)
Mean IU ALT (range)2280 (850–3760)2678 (658–4600)
Risk exposure:
 IDU (%)4/50 (8.0) §8/30 (26.7) §
 other parenteral (sexual, household contact) (%)20/50 (40.0)7/30 (23.3)
 unknown (%)26/50 (52.0)16/30 (53.3)
HBV genotype (%):
 A6/50 (12.0)6/30 (20.0)
 D43/50 (86.0)24/30 (80.0)
 E1/50 (2.0)
HBV-D sub-genotype (%) a
 D11/29 (3.4)1/16 (6.2)
 D23/29 (10.3)2/16 (12.5)
 D325/29 (86.2)13/16 (81.2)
  1. § p = 0.048, Fisher’s test
  2. asub-genotype could be determined for 29 genotype D cases in the 1978–79 group and 16 cases in the 1994–95 group