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Table 2 Clinical characteristics of the 384 subjects of our study cohort by ATS/IDSA criteria

From: Clinical relevance of pulmonary non-tuberculous mycobacterial isolates in three reference centres in Belgium: a multicentre retrospective analysis

 Total cohort (n = 384)ATS/IDSA + (n = 165)ATS/IDSA - (n = 219)ORa [CI 95%]aORb [CI 95%]
Demographyn (%)n (%)n (%)  
Median age in years (IQR)c65 (54–74)64 (52–74)67 (55–75)
Male232 (60.4%)94 (57%)138 (63%)0.78 [0.51–1.17]
Smoking historyd217 (56.5%)96 (58.2%)121 (55.3%)1.03 [0.68–1.57]
Comorbiditye
 Non-CF bronchiectasis60 (15.6%)33 (20%)27 (12.3%)1.74 [1.00–3.03]
 Cystic fibrosis24 (6.3%)10 (6.1%)14 (6.4%)0.93 [0.40–2.14]
 COPD/emphysema159 (41.4%)69 (41.8%)90 (41.1%)1.00 [0.66–1.51]
 Previous NTM disease31 (8.1%)23 (13.9%)8 (3.7%)4.19 [1.82–9.63]
 Previous TB disease32 (8.3%)12 (7.3%)20 (9.1%)0.76 [0.36–1.61]
 Pulmonary aspergillosis16 (4.2%)7 (4.2%)9 (4.1%)1.01 [0.37–2.78]
 Gastroesophageal reflux28 (7.3%)8 (4.8%)20 (9.1%)0.50 [0.21–1.16]
 Active malignancy63 (16.4%)28 (17%)35 (16%)1.05 [0.61–1.81]
 Immunodeficiency91 (23,7%)44 (26,7%)47 (21.5%)1.30 [0.81–2.09]
 Transplantation22 (5.7%)9 (5.5%)13 (5.9%)0.90 [0.37–2.15]
 Other127 (33.1%)52 (31.5%)75 (34.2%)0.86 [0.56–1.33]
Symptomatologyf
 Fever68 (17.7%)40 (24.2%)28 (12.8%)2.11 [1.24–3.61]2.26 [1.12–4.56]
 Night sweats30 (7.8%)20 (12.1%)10 (4.6%)2.80 [1.27–6.16]
 Fatigue/malaise109 (28.4%)63 (38.2%)46 (21%)2.24 [1.43–3.53]
 Sputum192 (50%)90 (54.5%)102 (46.6%)1.31 [0.87–1.96]
 Chest pain41 (10.7%)20 (12.1%)21 (9.6%)1.26 [0.66–2.41]
 Cough278 (72.4%)135 (81.8%)143 (65.3%)2.20 [1.35–3.59]
 Dyspoea186 (48.4%)77 (46.7%)109 (49.8%)0.84 [0.56–1.25]
 Weight loss108 (28.1%)71 (43%)37 (16.9%)3.59 [2.25–5.74]2.47 [1.42–4.31]
 Hemoptysis63 (16.4%)35 (21.2%)28 (12.8%)1.78 [1.03–3.07]
 Other31 (8.1%)11 (6.7%)20 (9.1%)0.69 [0.32–1.48]
Radiology (chest CT)g
 Fibrocavitary lesions63 (16.4%)46 (27.9%)17 (7.8%)4.45 [2.44–8.12]11.0 [4.74–25.57]
 Nodular bronchiectatic lesions188 (49%)103 (54.8%)85 (38.8%)2.50 [1.64–3.81]7.34 [3.87–13.91]
 Other124 (32.3%)15 (12.1%)109 (49.8%)0.094 [0.052–0.17]
Microbiology
 AFB staining positive78 (20.3%)64 (38.8%)14 (6.4%)9.28 [4.96–17.34]5.20 [2.60–10.42]
Pseudomonas aeruginosah54 (14.1%)24 (14.5%)30 (13.7%)1.07 [0.60–1.90]
Aspergillus fumigatush70 (18.2%)42 (25.5%)28 (12.8%)2.32 [1.37–3.93]
  1. Frequencies are given as absolute numbers (percentage of column total). aOdds ratio and 95% confidence interval calculated from univariate analysis. Statistically significant differences in univariate analysis (two-sided p < 0.05) marked in bold. bAdjusted odds ratio based on results from multivariate analysis. cAge as median age (IQR) in years, no statistically significant difference with Mann-Whitney U test. Missing information for: d12, f6, g9 patients respectively. hFound as co-isolates with NTM