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Table 2 MIC, variants and CLSI interpretation of toxigenic C. diphtheriae isolates for penicillin and erythromycin

From: First-line antibiotic susceptibility pattern of toxigenic Corynebacterium diphtheriae in Indonesia

Antibiotics and biotype

MIC range (μg/L)

Interpretation according to CLSI M45A

S

I

R

Penicillin

< 0.016 to 2

74 (68.52%)

36 (31.48%)

0 (0%)

Gravis

 

1

24

0

Mitis

 

73

12

0

Erythromycin

< 0.016 to

92 (85.19%)

13 (12.04%)

3 (2.77%)

Gravis

> 256

9

13

3

Mitis

 

83

0

0

  1. Source: CLSI M45A (2015) penicillin for Corynebacterium spp. (S) ≤ 0.12 μg/L, (I) 0.25 to 2 μg/L, and (R) ≥4 μg/L; for erythromycin: (S) ≤ 0,5 μg/L, (I) 1 μg/L (R), and ≥ 2 μg/L; S=Susceptible; R = Resistant; I=Intermediate