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Table 2 Detail illustration of mutations in MPT64 gene and their effects in capilia negative cultures

From: Mutation in MPT64 gene influencing diagnostic accuracy of SD Bioline assay (capilia)

Sample NumberLiquid CultureZN SmearCapiliaMTBDR plus assayMutationPhenotypic effect
K1+++26th position G deletionFrameshift from 9th amino acid leading to stop codon after 41st amino acid
K2+++37th position C deletionFrameshift from 13th amino acid leading to stop codon after 41st amino acid
K3+++26th position G deletionFrameshift from 9th amino acid leading to stop codon after 41st amino acid
K4+++37th position C deletionFrameshift from 13th amino acid leading to stop codon after 37th amino acid
K5+++37th position C deletionFrameshift from 13th amino acid leading to stop codon after 41st amino acid
K6+++26th position G deletionFrameshift from 9th amino acid leading to stop codon after 41st amino acid
K7+++6th position G insertionFrameshift from 3rd amino acid leading to stop codon after 88th amino acid
K8+++37th position C deletionFrameshift from 13th amino acid leading to stop codon after 41st amino acid
K9+++26th position G deletionFrameshift from 9th amino acid leading to stop codon after 41st amino acid
K10+++6th position G insertionFrameshift from 3rd amino acid leading to stop codon after 88th amino acid
K11 (Control)++++No mutation