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Table 2 Detail illustration of mutations in MPT64 gene and their effects in capilia negative cultures

From: Mutation in MPT64 gene influencing diagnostic accuracy of SD Bioline assay (capilia)

Sample Number

Liquid Culture

ZN Smear

Capilia

MTBDR plus assay

Mutation

Phenotypic effect

K1

+

+

+

26th position G deletion

Frameshift from 9th amino acid leading to stop codon after 41st amino acid

K2

+

+

+

37th position C deletion

Frameshift from 13th amino acid leading to stop codon after 41st amino acid

K3

+

+

+

26th position G deletion

Frameshift from 9th amino acid leading to stop codon after 41st amino acid

K4

+

+

+

37th position C deletion

Frameshift from 13th amino acid leading to stop codon after 37th amino acid

K5

+

+

+

37th position C deletion

Frameshift from 13th amino acid leading to stop codon after 41st amino acid

K6

+

+

+

26th position G deletion

Frameshift from 9th amino acid leading to stop codon after 41st amino acid

K7

+

+

+

6th position G insertion

Frameshift from 3rd amino acid leading to stop codon after 88th amino acid

K8

+

+

+

37th position C deletion

Frameshift from 13th amino acid leading to stop codon after 41st amino acid

K9

+

+

+

26th position G deletion

Frameshift from 9th amino acid leading to stop codon after 41st amino acid

K10

+

+

+

6th position G insertion

Frameshift from 3rd amino acid leading to stop codon after 88th amino acid

K11 (Control)

+

+

+

+

No mutation