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Table 1 Study characteristics in Paucibacillary Leprosy

From: World Health Organization (WHO) antibiotic regimen against other regimens for the treatment of leprosy: a systematic review and meta-analysis

Study Study Design Country Follow Up (years) N Age (Years) Diagnosis Control Used Evaluated Outcome
2–3 LMT, 2001 [16] RCT India 1.5 236 Children and adults Clinical and bacteriologicala ROM (single monthly dose, children were given half the dose) -Clinical score
-Lesion resolution
-Tx failure
Babu, 1997 [17] RCT Multicenter 1.5 1483 Mean 23.5 Clinical and bacteriologicala ROM (single monthly dose) Clinical score
Balagon, 2010 [18] RCT Phillipines 12 124 MDT:33.5±13.2 35.1±15.2 NR 28 days of RFP + ofloxacin for 4w then 5 m of placebo -Relapse
-Cure
Bathe,1986 [19] RCT India 1 80 19–45 Clinical, bacteriological, immunological, histological MDT + clofazimine in alternative days for 6 m Clinical score
Deshmuk, 2003 [20] RCT India 0.5 32 23  30 years and 9 > 30 years Clinical and bacteriologicala ROM (single monthly dose) Clinical and histopathological score
Emmanuel, 2005 [21] RCT India 2 51 Children and adults Clinical and histological ROM (single monthly dose) Clinical score
Katoch, 1999 [22] RCT India 2 300 NR NR MDT + clofazimine -Active disease/signs of activity
-Mitsuda reaction
-Relapse
Kumar 2015 [23] RCT India 8 268 Mean 38.3 Skin lesions and nerve involvement ROM (Single monthly dose) Cure and relapse
Manickam 2012 [24] RCT India 3 1526 Mean 27 Skin lesions and nerve involvement ROM (single dose, children were given half the dose) -Clinical score
-Complete clearance
Mathai, 1991 [25] RCT India 2 54 7–67 NR MDT + dapsone Mitsuda reaction
Orege, 1990 [26] RCT Kenya 0.6 127 NR Clinical MDT + RFP + dapsone Clinical score
Rao, 2009 [27] Not randomized India 2 32 NR Clinical RFP + dapsone + clofazimine ×  6 m Clinical and histopathological score
  1. Abbreviations.- BI Bacilar index, MDT Multidrug Treatment (WHO), NR Not reported, PB Paucibacilar, RFP Rifampin, ROM Rifampin-ofloxacin-minocycline, Tx Treatment, RCT Randomized Controlled Trial
  2. aNo further details provided