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Table 5 Multivariable analysis of predictors of first line ART treatment failure among HIV positive adult patients at St. Luke Referral hospital and Tulubolo General Hospital, 2019

From: Determinants of first line antiretroviral therapy treatment failure among adult patients on ART at central Ethiopia: un-matched case control study

Variables CasesControlCOR(95% CI)AOR(95% CI)P value
SexMale629711 
Female551360.63(.40,.98)0.65(0.37,1.14)0.137
OI after ART started.Yes951481  
No22850.40(0.23,0.68)0.56(0.28,1.09)0.089
History of malnutritionYes212511 
No962080.54(0.29,1.03)0.55(0.25,1.23)0.151
Base line opportunistic infectionYes921233.29(1.97,5.48)1.97(1.06,3.63)0.030*
No2511011 
LFUYes20143.22(1.56,6.65)3.66(1.44,9.27)0.006*
No9721911 
Adherence statusGood8119511 
Fair15251.44(0.72,2.88)1.48(0.64,343)0.357
Poor21133.88(1.85,8.13)1.70(0.70,4.12)0.233
NNRTI ART basedEFV base4616511 
NVP base71683.74(2.34,5.96)2.77(1.22,6.28)0.014*
Duration on First line ART< 5 yr171001  
> = 5 yr1001334.42(2.48,7.86)3.42(1.63,7.19)0.001*
Baseline Cd4< 10046324.06(2.40,6.88)2.72(1.46,5.07)0.002*
> = 1007120111 
Base line ART NRTITDF base4915611 
AZ based48443.47(2.06,5.8)1.05(0.44,2.50)0.895
D4Tbased20331.92(1.01,3.66)39(0.13,1.10)0.770
ART drug toxicityYes171111 
No1002220.29(0.13,.64)0.42(0.16,1.08)0.072
Time lag to initiate ART after confirmed HIV positiveIn the Same month217111 
In 1 to 24 month781461.80(1.03,3.15)2.14(1.06,4.34)0.033*
After 24 month18163.80(1.65,8.73)3.82(1.37,10.6)0.010*
Tuberculosis co-infection (at initial)Yes171211 
No1002210.31(0.14,0.69)0.50(0.20,1.24)0.138
1st line ART substitutionYes434811 
No741850.44(0.27,0.730.59(0.29,1.18)0.136