Table 1 A summary of case reports of Talaromyces marneffei oro-pharyngo-laryngitis
Country, no. of case (Year) | Age (yrs.)/ Sex | Predisposing conditions | Duration of symptoms | Clinical manifestations | Diagnosis | Treatments | Outcomes |
|---|---|---|---|---|---|---|---|
Thailand, 2 (1997) [19] | 29/ F, na/ F | HIV infection | na | Painful oral papules and skin papules (1); Oral ulcerations (1) | Tissue culture, histopathology | na | na |
Thailand, 1 (2000) [8] | 25/ F | HIV infection | 3 months | Sore throat, multiple oral papules | Microscopic exam, tissue culture | Oral KET, ART | Cure |
Hong Kong, 1 (2001) [7] | 63/ M | HIV infection | 2 months | Painful multiple oral ulcerations | Tissue, urine and blood cultures, histopathology | IV AMB, then oral ITRA, ART | Cure |
China, 1 (2012) [20] | 39/ M | None | 4 months | Chronic painful granuloma like oral ulceration | Histopathology, molecular assay, electron microscopy | Oral ITRA | Cure |
India, 1 (2017) [21] | 33/ M | HIV infection | 2 months | Fever, hoarseness, odynophagia, multiple skin papules | Tissue culture, histopathology | IV AMB, then oral ITRA, ART | Cure |
China, 7 (2017) [6] | Median 34/ M (7) | HIV infection (7) | na | Fever (7), sore throat (7), regional lymphadenopathy (7), mucosal ulceration (6), skin lesions (5), hepatosplenomegaly (5), hoarseness (4), local mass (4) | Tissue culture, blood culture, histopathology | IV AMB, then oral antifungals (FLU, ITRA) (5), ART (7) | Dead (3), improved (4) |
The present case | 52/F | Anti-IFNɣ autoantibodies | 3 weeks | Fever, sore throat, hoarseness, odynophagia | Microscopic exam, tissue culture, histopathology | IV AMB, then oral ITRA | Cure |