Skip to main content
Fig. 4 | BMC Infectious Diseases

Fig. 4

From: Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy

Fig. 4

Significant correlation between circulating levels of RAGE ligands and glycemic parameters and elevated circulating levels of RAGE ligands in KDM individuals. a The relationship between the plasma levels of AGE, sRAGE, S100A12 and HMGB-1 and HbA1c levels was examined in all TB participants with and without DM at baseline. b The plasma levels of AGE, sRAGE, S100A12 and HMGB-1 were measured in TB-DM individuals with known diabetes (KDM) versus newly diagnosed diabetes (NDM) (c) The plasma levels of AGE, sRAGE, S100A12 and HMGB-1 were measured in KDM individuals on metformin treatment versus no metformin treatment. The data are illustrated as scatter plots with each circle representing a single participant. For HbA1c correlations, P values were calculated using the Spearman Rank Correlation. For KDM, P values were calculated using the Mann-Whitney test with Holm’s correction for multiple comparisons

Back to article page