TY - JOUR AU - Komatsu, Haruki AU - Inui, Ayano AU - Suzuki, Yasuto AU - Sugiyama, Masaya AU - Fujisawa, Tomoo PY - 2019 DA - 2019/11/21 TI - Deep sequencing of hepatitis B surface antigen gene in the preserved umbilical cords in immunoprophylaxis failure against mother-to-child HBV transmission JO - BMC Infectious Diseases SP - 985 VL - 19 IS - 1 AB - Vaccine escape mutants (VEMs) are one of the causes of breakthrough infections in the mother-to-child transmission of hepatitis B virus (HBV). We hypothesized that VEMs existing as minor populations in the maternal blood are associated with breakthrough infections in children. We sought to determine whether VEMs exist as minor populations in the preserved umbilical cords of children with breakthrough infections. SN - 1471-2334 UR - https://doi.org/10.1186/s12879-019-4624-9 DO - 10.1186/s12879-019-4624-9 ID - Komatsu2019 ER -