Author [reference No.] | Song et al. | Takahashi et al. [20] | Behnes et al. [35] | Hamed et al. [32] | Harbarth et al. [16] | Jekarl et al. [19] | Mat-Nor et al. [36] | Miguel-Bayarri et al. [18] |
---|---|---|---|---|---|---|---|---|
Year of publication | 2019 | 2016 | 2014 | 2017 | 2001 | 2013 | 2016 | 2011 |
Definitions | Sepsis-3 | Sepsis-2 | Sepsis-2 | Sepsis-3 | Sepsis-2 | Sepsis-2 | Sepsis-2 | Sepsis-2 |
Setting | ED | ICU | ICU | ICU | ICU | ED | ICU | ICU |
Biomarkers | IL-6, PTX3 PCT, CRP | IL-6, PCT, presepsin, CRP | IL-6, PCT, presepsin, CRP | IL-6, PTX3, PCT, CRP | IL-6, PCT, IL-8 | IL-6, PCT, CRP | IL-6, PCT | IL-6, PCT, CRP |
Case | Sepsis | Severe sepsis, septic shock | Septic shock | Sepsis | Sepsis | Severe sepsis, septic shock | Sepsis | Severe sepsis, septic shock |
Control | Healthy control, Patient control | No infection with organ dysfunction | Patient control, SIRS, sepsis, severe sepsis | Healthy control, patient control | SIRS | SIRS, sepsis | SIRS | – |
Diagnostic value | IL-6> PTX3> PCT > CRP | IL-6 > PCT > CRP> presepsin | IL-6 > PCT > presepsin > CRP | IL-6 = PTX3 = PCT > CRP | PCT > IL-6 > IL-8 | PCT > IL-6 > CRP | PCT > IL-6 | – |
Most valuable prognostic marker | IL-6 | IL-6 | – | – | – | IL-6 | – | IL-6 |