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Table 7 Studies on the Clinical Value of Biomarkers Including Interleukin-6 in Sepsis Patients

From: Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions

Author [reference No.]

Song et al.

Takahashi et al. [20]

Behnes et al. [35]

Hamed et al. [32]

Harbarth et al. [16]

Jekarl et al. [19]

Mat-Nor et al. [36]

Miguel-Bayarri et al. [18]

Year of publication

2019

2016

2014

2017

2001

2013

2016

2011

Definitions

Sepsis-3

Sepsis-2

Sepsis-2

Sepsis-3

Sepsis-2

Sepsis-2

Sepsis-2

Sepsis-2

Setting

ED

ICU

ICU

ICU

ICU

ED

ICU

ICU

Biomarkers

IL-6, PTX3

PCT, CRP

IL-6, PCT, presepsin, CRP

IL-6, PCT, presepsin, CRP

IL-6, PTX3, PCT, CRP

IL-6, PCT, IL-8

IL-6, PCT, CRP

IL-6, PCT

IL-6, PCT, CRP

Case

Sepsis

Severe sepsis, septic shock

Septic shock

Sepsis

Sepsis

Severe sepsis, septic shock

Sepsis

Severe sepsis, septic shock

Control

Healthy control,

Patient control

No infection with organ dysfunction

Patient control, SIRS, sepsis, severe sepsis

Healthy control, patient control

SIRS

SIRS, sepsis

SIRS

–

Diagnostic value

IL-6> PTX3> PCT > CRP

IL-6 > PCT > CRP> presepsin

IL-6 > PCT > presepsin > CRP

IL-6 = PTX3 = PCT > CRP

PCT > IL-6 > IL-8

PCT > IL-6 > CRP

PCT > IL-6

–

Most valuable prognostic marker

IL-6

IL-6

–

–

–

IL-6

–

IL-6

  1. ED emergency department, ICU intensive care unit, IL-6 interleukin-6, PTX3 pentraxin 3, PCT procalcitonin, CRP C-reactive protein