Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions

Table 4 Univariate and Multivariate Cox Proportional Models of Risk Factors for 28-day Mortality

Variable	HR (95% CI)	P value	Adjusted HR (95% CI)	P value
Age	1.023 (0.994–1.052)	0.120
Male sex	1.029 (0.535–1.978)	0.932
SOFA score	1.206 (1.076–1.353)	0.001	1.128 (1.030–1.211)	0.011
APACHE II score	1.198 (1.068–1.346)	0.001	1.031 (0.898–1.187)	0.231
Pentraxin 3	1.005 (1.001–1.009)	0.031	1.003 (0.998–1.008)	0.095
Interleukin 6	1.001 (1.000–1.002)	0.017	1.001 (1.000–1.002)	0.024
Procalcitonin	0.995 (0.981–1.009)	0.481
Lactate	1.167 (1.068–1.275)	0.001	1.135 (1.033–1.247)	0.009
CRP	1.011 (0.978–1.045)	0.525
Septic shock	2.657 (1.327–5.317)	0.004	1.249 (0.472–3.302)	0.240

HR hazard ratio, CI confidence interval, GCS Glasgow coma scale, SOFA sequential organ-failure assessment, APACHE acute physiology and chronic health evaluation, CRP C-reactive protein

ISSN: 1471-2334