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Table 3 Liver-Specific characteristics of HIV-infected participants by HBV infection status (N = 2419)

From: Characteristics and outcomes of antiretroviral-treated HIV-HBV co-infected patients in Canada

Clinical Characteristics

HIV N = 2220

HIV-HBV Co-Infected N = 199

p valuea

Hepatitis C co-infection

520 (23)

61 (31)

0.02

Baseline AST (IU/L)

29 (23–41)

36 (26–62)

< 0.0001

Baseline AST category

 Normal (10–40 IU/L)

1649 (74)

120 (60)

< 0.0001

 Elevated (> 40 IU/L)

571 (26)

79 (40)

End of follow-up AST

25 (20–33)

26 (20–38)

0.14

End of follow-up AST category

 Normal (10–40 IU/L)

1855 (84)

152 (76)

0.01

 Elevated (> 40 IU/L)

365 (17)

47 (24)

Baseline APRI

0.37 (0.27–0.59)

0.50 (0.35–1.04)

< 0.0001

Baseline APRI Fibrosis category

  ≤ 0.5 (minimal)

1501 (68)

99 (50)

< 0.0001b

 0.51–1.49 (moderate)

593 (27)

68 (34)

 1.50–1.99 (significant)

34 (2)

8 (4)

  ≥ 2.0 (advanced/cirrhosis)

92 (4)

24 (12)

End of follow-up APRI

0.30 (0.22–0.43)

0.32 (0.23–0.56)

0.03

End of follow-up APRI Fibrosis category

  ≤ 0.5 (minimal)

1831 (82)

145 (73)

0.005b

 0.51–1.49 (moderate)

302 (14)

39 (20)

 1.50–1.99 (significant)

24 (1)

3 (2)

  ≥ 2.0 (advanced/cirrhosis)

63 (3)

12 (6)

  1. AST aspartate aminotransferase, APRI aspartate aminotransferase to platelet ratio index, VS virological suppression, FARVDT first naïve ARV date
  2. aData shown are frequencies and proportions for categorical variables and median and interquartile ranges for continuous variables. p values for continuous variables were calculated using chi-square or Fisher exact tests and for continuous variables were calculated using Wilcoxon’s Rank Sum tests
  3. bp values were calculated using Kruskal-Wallis rank tests