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Table 1 Characteristics of patients by age group and overall

From: The 2017–2018 influenza season in Bucharest, Romania: epidemiology and characteristics of hospital admissions for influenza-like illness

Characteristic< 1 y
N = 39
1–2 y
N = 111
3–4 y
N = 77
5–13 y
N = 103
14–17 y
N = 7
18–64 y
N = 135
≥65 y
N = 30
Overall
N = 502
Age (y), median [IQR]0.7 [0.4–0.9]1 [1–2]4 [3–4]7 [6–9]15 [15–16.5]45 [35–55]76 [68.3–80.8]5.5 [2–36]
Sex, n (%)
 Male20 (51.3)60 (54.1)41 (53.2)57 (55.3)5 (71.4)46 (33.8)15 (50.0)244 (48.6)
 Female19 (48.7)51 (45.9)36 (46.8)46 (44.7)2 (28.6)89 (65.9)15 (50.0)258 (51.4)
Smoking status, n (%)a
 Never smoked25 (64.1)27 (24.3)44 (57.1)63 (61.2)7 (100.0)61 (45.2)10 (33.3)282 (56.2)
 Past smoker4 (10.3)12 (10.8)9 (11.7)8 (7.8)0 (0.0)32 (23.7)15 (50.0)80 (15.9)
 Current smoker10 (25.6)72 (64.9)24 (31.2)32 (31.1)0 (0.0)42 (31.1)5 (16.7)140 (27.9)
Comorbidities, n (%)
 Any1 (2.6)6 (5.4)2 (2.6)8 (7.8)2 (28.6)64 (47.4)25 (83.3)108 (21.5)
 Cardiovascular disease0 (0.0)1 (0.9)0 (0.0)0 (0.0)0 (0.0)30 (22.2)23 (76.7)54 (10.8)
 COPD0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)6 (4.4)4 (13.3)10 (2.0)
 Asthma0 (0.0)1 (0.9)1 (1.3)4 (3.9)0 (0.0)3 (2.2)1 (3.3)10 (2.0)
 Diabetes0 (0.0)0 (0.0)0 (0.0)1 (1.0)1 (14.3)11 (8.1)6 (20.0)19 (3.8)
 Immunodeficiency1 (2.6)3 (2.7)1 (1.3)1 (1.0)1 (14.3)11 (8.1)0 (0.0)18 (3.6)
 Renal impairment1 (2.6)0 (0.0)0 (0.0)1 (1.0)0 (0.0)5 (3.7)2 (6.7)9 (1.8)
 Autoimmune disease0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)10 (7.4)2 (6.7)12 (2.4)
 Neuromuscular disease0 (0.0)1 (0.9)0 (0.0)0 (0.0)0 (0.0)6 (4.4)7 (23.3)14 (2.8)
 Cirrhosis/liver disease0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)21 (15.6)1 (3.3)22 (4.4)
 Neoplasm0 (0.0)0 (0.0)0 (0.0)1 (1.0)0 (0.0)3 (2.2)2 (6.7)6 (1.2)
Pregnant, n (%)0 (0.0)7 (5.2)7 (1.4)
ILI symptoms, n (%)
 Fever101 (98.1)7 (100.0)109 (80.7)25 (83.3)242 (88.4)b
 Malaise90 (87.4)7 (100.0)128 (94.8)27 (90.0)252 (91.6)b
 Headache70 (68.0)6 (85.7)109 (80.7)17 (56.7)202 (73.5)b
 Myalgia39 (37.9)5 (71.4)99 (73.3)19 (63.3)162 (58.9)b
 Cough92 (89.3)6 (85.7)111 (82.2)27 (90.0)236 (85.8)b
 Sore throat77 (74.8)7 (100.0)77 (57.0)11 (36.7)172 (62.5)b
 Shortness of breath15 (14.6)4 (57.1)65 (48.1)21 (70.0)105 (38.2)b
 Tachypneac2 (5.1)11 (9.9)15 (19.5)28 (12.3)d
Hospitalizations in previous 12 mo, n (%)
 18 (20.5)30 (27.0)22 (28.6)19 (18.4)1 (14.3)14 (10.4)e10 (33.3)104 (20.8)f
 ≥ 28 (20.5)19 (17.1)14 (18.2)11 (10.7)1 (14.3)10 (7.5)e5 (16.7)68 (13.6)f
Outpatient consultations in previous 3 mo, n (%)
 111 (29.0)g26 (23.4)15 (19.7)h17 (16.5)2 (28.6)22 (16.4)e8 (26.7)101 (20.2)i
 ≥ 211 (29.0)g50 (45.0)34 (44.7)h41 (39.8)1 (14.3)14 (10.4)e5 (16.7)156 (31.3)i
Vaccinated against influenza in 2017–2018, n (%)0 (0.0)j0 (0.0)0 (0.0)0 (0.0)0 (0.0)17 (12.6)0 (0.0)17 (3.4)
 ≥ 14 days before ILI onsetk0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)10 (7.4)0 (0.0)10 (2.0)
 Patients with comorbiditiesl0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)8 (12.5)0 (0.0)8 (7.4)
Vaccinated in previous seasons, n (%)
 2016–20170 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)14 (10.4)1 (3.3)15 (3.0)
 2015–20160 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)17 (12.6)2 (6.7)19 (3.8)
Duration of hospitalization (days), median [IQR]5 [4–6.75]g5 [3–6.5]5 [4–6]5 [4–7]m5 [4.5–8.5]5 [3–7]7 [6–9.5]5 [3–7]i
Antiviral treatment prescribed, n (%)38 (97.4)108 (97.3)76 (98.7)99 (96.1)5 (71.4)106 (78.5)22 (73.3)454 (90.4)
Intensive care received, n (%)
 ICU admission0 (0.0)4 (3.6)1 (1.3)2 (1.9)0 (0.0)4 (3.0)0 (0.0)11 (2.2)
 Mechanical ventilation0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)1 (0.7)0 (0.0)1 (0.2)
Death while hospitalized, n (%)0 (0.0)0 (0.0)0 (0.0)0 (0.0)0 (0.0)1 (0.7)0 (0.0)1 (0.2)
  1. Abbreviations: COPD Chronic obstructive pulmonary disease, ICU Intensive care unit, ILI Influenza-like illness, IQR Interquartile range
  2. a For patients aged 0–13 years of age, smoking habits refer to parents or tutors
  3. b Percentage of patients aged ≥5 years (N = 275)
  4. c Recorded only for patients aged 0–4 years. For patients aged 0–11 months, defined as > 50 breaths per minute; for patients 12–60 months, defined as > 40 breaths per minute
  5. d Percentage of patients aged 0–4 years (N = 227)
  6. e N = 134
  7. f N = 501
  8. g N = 38
  9. h N = 76
  10. i N = 499
  11. j Influenza vaccination was contraindicated for 17 patients because they were aged < 6 months
  12. k Percentage of patients in each age group
  13. l Percentage of patients with comorbidities
  14. m N = 101
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