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Table 4 distribution of PMQR and QRDRs among different FQs resistance phenotypes of Enterobacteriaceae isolated from UTIs

From: Impact of co-existence of PMQR genes and QRDR mutations on fluoroquinolones resistance in Enterobacteriaceae strains isolated from community and hospital acquired UTIs

SpeciesPhenotypeResistant to QuinolonesPMQR genesMIC of CIP (μg/mL)NumbergyrA alterationsParC alterations
E.coliFQ SusceptibleNA onlyNo genes detected0.531Ser83LeuNo mutation
0.2519Ile155PheSer80Ile
Intermediate resistanceNA, CIP, NOR, OFXqnrB1.57His80Met
Gly81Ala
Ser83Leu
Met118Trp
Arg119Val
213Ser83LeuNo mutation
High resistanceNA, CIP, NOR, OFXqnrB, qnrS12828Ser83Tyr
Lys154Arg
Ser171Ala
Ile174Thr
Ala175Val
Ser80Ile
High resistanceNA, CIP, NOR, OFXqnrB, qnrS, qepA128, 256, 5126Asp87AsnSer80Ile
K. pneumoniaeFQ SusceptibleNA onlyNo genes detected0.52Lys154Arg
Ala171Ser
No mutation
Intermediate resistanceNA, CIP, NOR, OFXqnrB22No mutationSer80Ile
High resistanceNA, CIP, NOR, OFXqnrB, qnrS1283Ser83TyrSer80Ile
Met118Ile
5124Ser83Tyr
Ala175Arg
Val176Leu
Ser80Ile
Met118Ile
Citrobacter spp.Intermediate resistanceNA, CIP, NOR, OFXqnrB1.51NDND
High resistanceNA, CIP, NOR, OFXqnrB, qnrS25615Ser83Ile
Lys154Arg
Ser171Ala
Ser80Ile
High resistanceNA, CIP, NOR, OFXqnrB, qnrS, qepA5121
Enterobacter spp.FQ susceptibleNA onlyNo genes detected0.1251NDND
Proteus spp.High resistanceNA, CIP, NOR, OFXqnrB, qnrS125–5128NDND
High resistanceNA, CIP, NOR, OFXqnrB, qnrS, qepA2NDND
  1. PMQR Plasmid-mediated quinolone resistance, QRDR Quinolone resistance determining regions, CIP Ciprofloxacin, ND Not determined