Table 4 distribution of PMQR and QRDRs among different FQs resistance phenotypes of Enterobacteriaceae isolated from UTIs
Species | Phenotype | Resistant to Quinolones | PMQR genes | MIC of CIP (μg/mL) | Number | gyrA alterations | ParC alterations |
|---|---|---|---|---|---|---|---|
E.coli | FQ Susceptible | NA only | No genes detected | 0.5 | 31 | Ser83Leu | No mutation |
0.25 | 19 | Ile155Phe | Ser80Ile | ||||
Intermediate resistance | NA, CIP, NOR, OFX | qnrB | 1.5 | 7 | His80Met Gly81Ala Ser83Leu | Met118Trp Arg119Val | |
2 | 13 | Ser83Leu | No mutation | ||||
High resistance | NA, CIP, NOR, OFX | qnrB, qnrS | 128 | 28 | Ser83Tyr Lys154Arg Ser171Ala Ile174Thr Ala175Val | Ser80Ile | |
High resistance | NA, CIP, NOR, OFX | qnrB, qnrS, qepA | 128, 256, 512 | 6 | Asp87Asn | Ser80Ile | |
K. pneumoniae | FQ Susceptible | NA only | No genes detected | 0.5 | 2 | Lys154Arg Ala171Ser | No mutation |
Intermediate resistance | NA, CIP, NOR, OFX | qnrB | 2 | 2 | No mutation | Ser80Ile | |
High resistance | NA, CIP, NOR, OFX | qnrB, qnrS | 128 | 3 | Ser83Tyr | Ser80Ile Met118Ile | |
512 | 4 | Ser83Tyr Ala175Arg Val176Leu | Ser80Ile Met118Ile | ||||
Citrobacter spp. | Intermediate resistance | NA, CIP, NOR, OFX | qnrB | 1.5 | 1 | ND | ND |
High resistance | NA, CIP, NOR, OFX | qnrB, qnrS | 256 | 15 | Ser83Ile Lys154Arg Ser171Ala | Ser80Ile | |
High resistance | NA, CIP, NOR, OFX | qnrB, qnrS, qepA | 512 | 1 | |||
Enterobacter spp. | FQ susceptible | NA only | No genes detected | 0.125 | 1 | ND | ND |
Proteus spp. | High resistance | NA, CIP, NOR, OFX | qnrB, qnrS | 125–512 | 8 | ND | ND |
High resistance | NA, CIP, NOR, OFX | qnrB, qnrS, qepA | 2 | ND | ND |