Skip to main content

Table 1 Patient characteristics and incidence (episode/1000 admission)

From: Surveillance study of the prevalence, species distribution, antifungal susceptibility, risk factors and mortality of invasive candidiasis in a tertiary teaching hospital in Southwest China

 

Candida species

Total

C. albicans

C. glabrata

C. tropicalis

C. krusei

C. parapsilosis

Othersh

(n = 243)

100.0%

(n = 110)

45.3%

(n = 73)

30.0%

(n = 37)

15.2%

(n = 12)

4.9%

(n = 5)

2.1%

(n = 6)

2.5%

Patient characteristics

 Age (years)

  16–49

70 (28.8)

32 (45.7)

23 (32.8)

8 (11.4)

3 (4.3)

2 (2.9)

2 (2.9)

  50–65

84 (34.6)

24 (28.6)

35 (41.6)

15 (17.9)

6 (7.1)

2 (2.4)

2 (2.4)

   > 65

89 (36.6)

54 (60.7)

15 (16.9)

14 (15.7)

3 (3.4)

1 (1.1)

2 (2.2)

 Gender

  Male

139 (57.2)

60 (43.2)

41 (29.5)

28 (20.1)

4 (2.9)

4 (2.9)

2 (1.4)

  Female

10 4 (42.8)

50 (48.1)

32 (30.8)

9 (8.7)

8 (7.7)

1 (0.9)

4 (3.8)

 Underlying comorbidities (n, %)

  Gastrointestinal perforation

48 (19.6)

24 (50.0)

10 (20.8)

8 (16.7)

5 (10.4)

0 (0)

1 (2.1)

  Respiratory dysfunctiona

51 (21.0)

25 (49.0)

16 (31.4)

9 (17.6)

0 (0)

0 (0)

1 (2.0)

  Pulmonary infection

81 (33.3)

43 (53.1)

20 (24.7)

14 (17.3)

1 (1.2)

1 (1.2)

2 (2.5)

  Cardiovascular disease

78 (32.1)

41 (52.6)

20 (25.6)

10 (12.8)

5 (6.4)

0 (0)

2 (2.6)

  Neurological diseases

58 (23.9)

35 (60.4)

10 (17.2)

9 (15.5)

2 (3.5)

1 (1.7)

1 (1.7)

  Gastrointestinal pathologyb

63 (25.9)

32 (50.8)

18 (28.6)

7 (11.1)

5 (7.9)

1 (1.6)

0 (0)

  Chronic/acute liver disease

45 (18.5)

22 (48.9)

9 (0.2)

10 (22.2)

3 (6.7)

1 (2.2)

0 (0)

  Chronic/acute renal failurec

90 (37.0)

48 (53.3)

23 (25.6)

15 (16.7)

2 (2.2)

0 (0)

2 (2.2)

  Solid tumour

22 (9.1)

11 (50.0)

2 (9.1)

7 (31.8)

2 (9.1)

0 (0)

0 (0)

  Haematological malignancy

6 (2.5)

3 (50.0)

1 (16.7)

1 (16.7)

0 (0)

0 (0)

1 (16.6)

  Severe autoimmune diseases

11 (4.5)

7 (63.6)

0 (0)

3 (27.3)

1 (9.1)

0 (0)

0 (0)

  Diabetes mellitus

93 (38.3)

57 (61.3)

19 (20.4)

11 (11.8)

6 (6.5)

0 (0)

0 (0)

  Burns

6 (2.5)

2 (33.3)

1 (16.7)

1 (16.7)

0 (0)

2 (33.3)

0 (0)

  HIV/AIDS

13 (5.3)

2 (15.4)

10 (76.9)

0 (0)

0 (0)

0 (0)

1 (7.7)

  Severe trauma

15 (6.2)

6 (40.0)

3 (20.0)

4 (26.6)

1 (6.7)

1 (6.7)

0 (0)

 Risk factors (n, %)

  Presence of CVCd

118 (48.6)

59 (50.0)

23 (19.5)

24 (20.3)

8 (6.8)

2 (1.7)

2 (1.7)

  Mechanical ventilation

82 (33.7)

41 (50.0)

19 (23.2)

15 (18.3)

5 (6.1)

1 (1.2)

1 (1.2)

  Receipt of corticosteroidse

70 (28.8)

43 (61.4)

12 (17.1)

14 (20.0)

1 (1.4)

0 (0)

0 (0)

  Total parenteral nutrition

119 (49.0)

62 (52.1)

29 (24.4)

19 (16.0)

7 (5.9)

1 (0.8)

1 (0.8)

  Chemotherapy

11 (4.5)

4 (36.4)

1 (9.1)

5 (45.4)

1 (9.1)

0 (0)

0 (0)

  Abdominal surgeryf

69 (28.4)

26 (37.7)

27 (39.1)

10 (14.5)

4 (5.8)

0 (0)

2 (2.9)

  Intensive care in adults

42 (17.3)

21 (50.0)

9 (21.4)

8 (19.0)

2 (4.8)

1 (2.4)

1 (2.4)

  Neutropeniag

7 (2.9)

4 (57.1)

0 (0)

1 (14.3)

2 (28.6)

0 (0)

0 (0)

  Concomitant bacterial infections

81 (33.3)

46 (56.8)

13 (16.0)

18 (22.3)

2 (2.5)

1 (1.2)

1 (1.2)

  Septic shock

46 (18.9)

16 (34.8)

19 (41.4)

7 (15.2)

2 (4.3)

0 (0)

2 (4.3)

  Dialysis

25 (10.3)

9 (36.0)

13 (52.0)

2 (8.0)

0 (0)

0 (0)

1 (4.0)

 Previous antibiotics therapy

215 (88.5)

103 (47.9)

60 (27.9)

35 (16.3)

12 (5.6)

1 (0.5)

4 (1.8)

  Treatment with antifungal agents

83 (34.2)

44 (53.0)

20 (24.1)

14 (16.9)

3 (3.6)

0 (0)

2 (2.4)

 Incidence (episodes/1000 admissions)

  2013

0.16

0.05

0.06

0.03

0.01

0

0.01

  2014

0.31

0.16

0.07

0.06

0.01

0

0.01

  2015

0.43

0.18

0.13

0.06

0.04

0.02

0

  2016

0.52

0.28

0.13

0.05

0.03

0

0.03

  2017

0.66

0.25

0.23

0.12

0.02

0.03

0.01

  1. aIncludes the following diseases: chronic obstructive pulmonary disease and acute respiratory distress syndrome
  2. bIncludes the following diseases: cholecystitis, pancreatitis, and peritonitis
  3. cChronic/Acute renal failure is the permanent or sudden and often temporary loss of kidney function with N waste retention and hypourocrinia
  4. dCVC central venous catheter
  5. ea dose equivalent to the prednisone dosage of 0.3 mg/kg/day for at least 14 days
  6. fincluding: gastrointestinal perforations, severe acute pancreatitis and complex ventral hernia
  7. gNeutropenia is the absolute neutrophil count, that is, < 500 cells/μl
  8. hOthers include C. guilliermondii (3), C. haemulonii (2) and C. pseudotropicalis (1)