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Table 4 The evaluation of diagnostic tests of syphilitic indicators for neurosyphilis

From: Clinical prediction and diagnosis of neurosyphilis in HIV-negative patients: a case-control study

VariableSensitivity (%)Specificity (%)AUC & 95% CIp value
Neurological symptoms46.0089.800.679 (0.578–0.769)< 0.001
CSF TPPA titer (cutoff > 1:160)90.0084.000.941 (0.876–0.978)< 0.001
CSF protein (cutoff > 497 mg/L)54.0085.710.710 (0.610–0.797)< 0.001
CSF WBC (cutoff > 3 cells/μL)48.0082.000.655 (0.553–0.747)0.003
A combination of the above tests except CSF TPPA92.0033.300.793(0.700–0.887)< 0.001
A combination of the above tests98.0040.800.786 (0.692–0.880)< 0.001
  1. AUC Area under curve, CSF Cerebrospinal fluid, TPPA Treponema pallidum particle agglutination, WBC White blood cell