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Table 2 Independent Predictors of tuberculosis development among tuberculosis close contact cohort by stratified multivariable Cox proportional hazard regression analysis

From: Impact of metformin use among tuberculosis close contacts with diabetes mellitus in a nationwide cohort study

Variables adjusted Hazard ratio (95% CI) p-value
DM and metformin status
 DM, metformin nonusers Reference  
 DM, metformin users 0.73 (0.54–0.98) 0.035
 Healthy cohort 0.42 (0.30–0.60) < 0.001
Statin users 0.58 (0.35–0.97) 0.038
Bronchiectasis 9.62 (1.09–84.81) 0.041
  1. Abbreviations: DM, diabetes mellitus
  2. Adjusted variables included age, male, adapted Diabetes Complications Severity Index, previous tuberculosis history, urban contact area, local TB incidence (/100,000 person-years), low income, medical visits in 3 months, statin users, type 1 diabetes mellitus, chronic obstructive pulmonary disease, liver cirrhosis, transplantation, acquired immunodeficiency syndrome, bronchiectasis, early adherent isoniazid preventive therapy, latent tuberculosis infection, use of statins, corticosteroids, insulin, and oral hypoglycemic agents other than metformin, malignancy, and other co-morbidities (pneumoconiosis, psoriasis, rheumatoid arthritis, and ankylosing spondylitis).