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Table 3 Risk factors of incident TB disease in participants receiving first-line ART with death and loss to follow-up as competing risks

From: Incidence of tuberculosis in HIV-infected adults on first- and second-line antiretroviral therapy in India

Characteristics

Overall

First-line ART

Second-line ART

Univariable

Multivariable

Univariable

Multivariable

Univariable

Multivariable

SHR (95%CI)

p-value

SHR (95%CI)

p-value

SHR (95%CI)

p-value

SHR (95%CI)

p-value

SHR (95%CI)

p-value

SHR (95%CI)

p-value

Age

 18–29

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

 30–39

1.09 (0.78–1.54)

0.58

1.00 (0.70–1.41)

0.99

1.15 (0.80–1.64)

0.44

1.02 (0.71–1.47)

0.90

0.92 (0.27–3.08)

0.89

0.95 (0.27–3.34)

0.94

 40–49

1.00 (0.69–1.45)

0.96

0.91 (0.62–1.33)

0.63

1.17 (0.80–1.72)

0.40

0.96 (0.65–1.43)

0.87

0.39 (0.10–1.44)

0.15

0.41 (0.08–1.90)

0.25

  > 50

0.94 (0.57–1.54)

0.80

0.84 (0.50–1.41)

0.51

1.12 (0.67–1.86)

0.64

0.94 (0.55–1.59)

0.83

Sex

 Female

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

 Male

1.31 (1.02–1.68)

0.03

1.33 (1.02–1.74)

0.03

1.44 (1.11–1.87)

0.006

1.35 (1.03–1.77)

0.02

0.96 (0.36–2.57)

0.94

1.14 (0.35–3.69)

0.81

CD4+ count at respective ART initiation (cells/mm3)

  > 350

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

 200–349

2.74 (1.41–5.33)

0.003

2.18 (1.09–4.36)

0.02

1.76 (0.84–3.68)

0.12

1.80 (0.86–3.76)

0.11

3.98 (0.81–19.51)

0.08

4.22 (0.89–19.94)

0.07

  < 200

4.90 (2.58–9.30)

< 0.001

3.75 (1.91–7.37)

< 0.001

3.04 (1.49–6.18)

0.002

3.03 (1.48–6.17)

0.002

8.80 (2.05–37-71)

0.003

9.95 (2.38–41.60)

0.002

Residence

 Semi-urban or rural

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

 Urban

1.56 (1.15–2.11)

0.004

1.53 (1.13–2.07)

0.006

1.38 (1.01–1.88)

0.03

1.42 (1.04–1.94)

0.02

4.52 (1.03–19.70)

0.04

4.60 (0.96–21.86)

0.05

ART

 First-line

Ref

 

Ref

 

 Second-line

0.34 (0.21–0.56)

< 0.001

0.48 (0.28–0.82)

0.008

Duration on first-line ART prior to second-line ART initiation

 Per-year increase

1.00 (0.99–1.01)

0.10

1.00 (0.99–1.00)

0.88

  1. SHR sub distribution hazard ratio, CI Confidence interval, Ref Reference group. All multivariable analyses included age, sex, CD4+ cell counts and residence. The overall multivariable analysis additionally included type of ART