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Table 1 Characteristics of included studies

From: Long term surgical outcomes for infective endocarditis in people who inject drugs: a systematic review and meta-analysis

Author

Year Published

Location

Period

PWID

n

Age, mean ± SD

Male, n (%)

Maximum follow-up (years)

Notes

Arbulu [39]

2000

Detroit, USA

1970–1990

Yes

55

NA ± NA

29

Kaplan Meier reported for 36 patients.

Asgeirsson [40]

2016

Karolinska, Sweden

2004–2013

Yes

10

38.7 ± 12.75

77 (64)

1

Data reported for surgical and non-surgical cases together.

    

No

27

65.6 ± 8.25

96 (77)

1

Baraki [41]

2013

Hannover, Germany

1996–2012

Yes

9

 

 

Demographic data reported together. IPD reported in table but survival for survivors not reported.

    

No

45

42 ± 16.2

37 (68.5)

5

Boyd [42]

1977

New York, USA

1970–1975

Yes

14

NA ± NA

15

Demographic data reported together. Kaplan Meier not separated by PWID and non-PWID.

    

No

19

49 ± 21

19 (57.6)

15

Carozza [43]

2004

Naples, Italy

1980–2004

Yes

39

32.1 ± 8.1

35 (89.7)

10.5

 
    

No

85

33.4 ± 8.2

57 (67.1)

10.5

 

Carrell [44]

1993

Zurich, Switzerland

1989–1991

Yes

10

23.4 ± 3.2

7 (70)

20

Reconstructed IPD from published table.

Dawood [45]

2015

Baltimore, USA

2002–2012

Yes

56

39 ± 12

23 (41.1)

11

Included 6 patients who were non-PWID

Frater [46, 47]

1989

Bronx, USA

1984–1987

Yes

9

NA ± NA

2.75

Reconstructed IPD from published table.

   

1977–1980

Yes

10

NA ± NA

9

No Kaplan Meier or patient table.

 

1990

Bronx, USA

1977–1989

Yes

57

NA ± NA

10

Combined previous cohorts

Hubbell [48]

1981

San Francisco, USA

1965–1976

Yes

27

33 ± 12.1

57 (72)

11

Demographic data reported together for surgical and non-surgical. Reconstructed IPD from published table.

Kaiser [49]

2007

St. Louis, USA

1986–2005

Yes

62

39 ± 9

37 (59.7)

19.1

Microbiologic data only for 31 of 62 in PWID.

    

No

284

54 ± 15

185 (65.1)

18.8

Kim [50]

2016

Boston, USA

2002–2014

Yes

78

35.9 ± 9.9

48 (61.5)

10

 
    

No

358

59.3 ± 14.1

247 (69)

10

 

Levitsky [51]

1982

Chicago, USA

1976–1981

Yes

37

34.6 ± NA

31 (83.8)

5

No SD reported. Age range 20–52

Mammana [52]

1983

Chicago, USA

1976–1979

Yes

18

33.7 ± 10.3

3

Reconstructed IPD from published table.

Martin-Davila [53]

2005

Madrid, Spain

1985–1999

Yes

26

33 ± NA

12

Non-PWID were excluded because they were not separated by surgical and non-surgical patients.

Marks [54]

2015

London, England

1998–2010

Yes

11

27.8 ± 4.8

52 days

Data reported together for surgical and non-surgical

Mathew [55]

1995

Chicago, USA

1982–1991

Yes

80

37.7 ± 10

58 (72.5)

7.5

 

Mestres [56]

2003

Barcelona, Spain

1985–2002

Yes

21

28.2 ± 6.5

18 (85.7)

10.8

 

Nelson [57, 58]

1984

Los Angeles, USA

1972–1982

Yes

27

32.9 ± NA

37 (7110)

10

Demographic data reported together for PWID and non-PWID. Group D streptococcus counted as enterococcus.

No SD reported. Age range 9–58

    

No

25

38 ± NA

 

10

Osterdal [59]

2016

Bergen, Norway

2001–2013

Yes

29

39.7 ± 11.2

27 (93.1)

9.4

 

Pfannmueller [60]

2015

Leipzing, Germany

1995–2012

Yes

11

33.5 ± 4.29

8 (72.7)

15

 
    

No

45

60.1 ± NA

31 (68.9)

15

Used meta-analysis of mean of two non-PWID groups to obtain mean age

Rabkin [61]

2012

Seattle, USA

1999–2010

Yes

64

43.5 ± 10.9

45 (70.3)

6.6

Grouped S. aureus and CONS. For analysis, considered as S. aureus.

    

No

133

48.4 ± 17.9

97 (72.9)

10.3

 

Shetty [62]

2016

Nova Scotia, Canada

2008–2011

Yes

7

33.4 ± 12.1

4 (57.1)

2

Reconstructed IPD from published table.

Shrestha [63]

2015

Cleveland, USA

2007–2012

Yes

41

38 ± 11

26 (63.4)

6

 
    

No

495

59 ± 14

342 (69.1)

6.4

 

Silverman [64]

1984

Chicago, USA

1976–1983

Yes

14

NA ± NA

11 (78.6)

7

 

Thalme [10]

2009

Stockholm, Sweden

1994–2000

Yes

60

39 ± 5.9

31 (51.7)

3.3

Combines both surgical and non-surgical. Reason for differences in n (5 PWID and 27 non-PWID)

    

No

135

64 ± 19.2

75 (55.6)

9.4

 

Weymann [65]

2014

Heidelberg, Germany

1993–2013

Yes

20

35 ± 7.7

13 (65)

16.6

 

Ying [66]

2013

Ottawa, Canada

2003–2012

Yes

24

39.4 ± 2.1

17 (70.8)

10

Reported as abstract, never published.

    

No

171

59.1 ± 1

127 (74.3)

10

 
  1. Abbreviations: CI Confidence interval, PWID People who inject drugs, non-PWID people who do not inject drugs, SD standard deviation