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Table 4 Risk ratios for TST positivity by demographic and clinical characteristic. Adjusted results are presented for complete case analysis (n = 1878 patientsa) and analysis using combined results of 20 imputed datasets (n = 2303 patients). Risk ratios marked with an asterisk (*) are statistically significant. CI = confidence interval

From: The latent tuberculosis infection cascade of care in Iqaluit, Nunavut, 2012–2016

Potential Risk factor Patients with positive TST/ category total (%) Risk ratio from univariate modelsb (95% CI) Adjusted risk ratioc (95% CI), complete case Adjusted risk ratioc (95% CI), multiple imputation
Age, years (per 5-year increase) 0.99 (0.97–1.02) 1.00 (0.97–1.04) 1.01 (0.98–1.04)
Sex
 Male 233/1065 (21.9%) Reference Reference Reference
 Female 223/138 (18.0%) 0.80 (0.68–0.95)* 0.78 (0.65–0.94)* 0.80 (0.68–0.95)*
Ethnicity
 Inuit 306/1220 (25.1%) Reference Reference Reference
 Non-Inuit 90/658 (13.7%) 0.58 (0.47–0.73)* 0.64 (0.50–0.83)* 0.68 (0.54–0.86)*
Indication for TST
 Tuberculosis exposure 199/606 (32.8%) Reference Reference Reference
 Employment screening 67/506 (13.2%) 0.45 (0.35–0.57)* 0.59 (0.45–0.78)* 0.58 (0.45–0.75)*
 School screening 34/297 (11.4%) 0.40 (0.28–0.57)* 0.36 (0.22–0.60)* 0.48 (0.33–0.70)*
 Self or physician referral 124/746 (16.6%) 0.62 (0.51–0.75)* 0.67 (0.55–0.83)* 0.69 (0.57–0.83)*
Year of TST
 2012 201/759 (26.5%) Reference Reference Reference
 2013 101/547 (18.5%) 0.64 (0.52–0.80)* 0.64 (0.51–0.80)* 0.65 (0.53–0.80)*
 2014 95/498 (19.1%) 0.75 (0.61–0.92)* 0.73 (0.59–0.92)* 0.77 (0.63–0.94)*
 2015 45/425 (10.6%) 0.39 (0.30–0.51)* 0.41 (0.30–0.56)* 0.45 (0.34–0.59)*
 2016 12/74 (16.2%) 0.66 (0.42–1.05) 0.75 (0.45–1.24) 0.77 (0.50–1.20)
  1. aData regarding ethnicity were missing for 472 TSTs (14.9%) in 425 patients (18.5%) and were estimated using multiple imputation. Data on indication were missing for 189 TSTs (6.0%) in 148 patients (6.4%)
  2. bUnivariate models adjusted for the correlation between multiple TSTs performed on the same individual using an exchangeable correlation matrix
  3. cModel included age, sex, ethnicity, indication for TST and year of TST and adjusted for multiple TSTs performed on the same individual using an exchangeable correlation matrix