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Table 1 Individual and cluster level characteristics of all study participants, stratified by Pfdhps and Pfcrt genotype

From: The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo

 

Pfdhps

Pfcrt

Wildtype (N = 81)

Any pfdhps mutation (N = 434)

P-value***

Wildtype (N = 306)

CVIET haplotype (N = 369)

P-value***

Malaria prevalence (SD)

59.3 (20.4)

58.9 (21.8)

0.872

60.04 (21.74)

57.42 (22.24)

0.125

Anti-malarial use during pregnancya (SD)

16.7 (16.6)

22.2 (18.1)

0.011

2.0 (6.2)

1.9 (6.0)

0.955

Anti-malarial use amongst children (SD)b

3.0 (6.4)

2.0 (5.6)

0.126

1.7 (4.4)

1.6 (4.0)

0.745

Mean DHS Cluster size (SD)

17.9 (18.0)

19.3 (18.8)

0.652

17.8 (19.07)

20.0 (22.14)

0.266

% without education (SD)

32.7 (23.48)

23.1 (21.5)

< 0.001

28.8 (24.41)

22.0 (20.16)

< 0.001

% in lowest wealth category (SD)

30.2 (23.0)

21.4 (22.5)

0.001

27.2 (22.5)

20.5 (22.5)

< 0.001

Number living in urban area (%)

28 (34.6)

154 (35.4)

0.975

90 (29.4)

135 (36.6)

0.059

Individual covariates:

 Number female (%)

41 (50.6)

228 (52.5)

0.845

153 (50.0)

192 (52.0)

0.654

 Median Individual Wealth Index (IQR)

2 (1–3)

3 (1–4)

0.015

2 (1–3)

3 (2–4)

< 0.001

  1. *** p-values for tests conducted for comparisons between wildtype and mutant groups (Chi-squared tests for categorical data and t-tests for continuous data)
  2. a Percentage of pregnant women reporting drug use; SP use is described by pfdhps status and chloroquine use by pfcrt status
  3. b Percentage of children with a cough or fever that received SP or chloroquine; SP use is described by pfdhps status and chloroquine use by pfcrt status