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Table 3 Changes of characteristics of severe HFMD caused by EV71 in the non-CVVHDF group and the CVVHDF group

From: Continuous hemodiafiltration as a rescue therapy for patients with cardiopulmonary failure caused by enterovirus-71: a retrospective observational study in a PICU

Variables Non-CVVHDF group
(n = 12)
CVVHDF group
(n = 17)
P”
1st day (A1) 3rd day (A2) P Before CVVHDF (B1) 72 h after CVVHDF (B2) P’
Vital signs
 Heart rate, bpm 188.0 (170.8, 194.8) 142.0 (130.3, 157.0) 0.001 187.0 (178.0, 197.5) 134.0 (122.5, 147.0) 0.001 0.143
 Body temperature, oC 39.7 (39.4, 39.8) 38.0 (37.3, 38.5) 0.001 39.7 (39.3, 40.0) 36.8 (36.4, 37.3) 0.001 0.001
 Systolic blood pressure, mmHg 132.0 (76.0, 150.5) 121.5 (103.5, 140.3) 0.854 139 (101.5, 155.0) 102.5 (86.5, 115.7) 0.003 0.001
Cardiac parameters
 LVEF, % 38 (26, 44) 41 (29, 46) 0.204 37 (21, 47) 55 (21, 62) 0.017 0.184
 CI, L/min/m2 2.89 (2.23, 3.63) 3.11 (2.22, 3.73) 0.621 2.73 (1.92, 3.95) 4.77 (1.92, 5.75) 0.002 0.199
 cTnI, μg/L 0.16 (0.06, 0.38) 0.08 (0.04, 0.15) 0.032 0.12 (0.06, 0.39) 0.02 (0.01, 0.48) 0.365 0.325
 CK-MB, IU/L 35.0 (20.5, 72.8) 33.0 (19.0, 64.3) 0.240 37.0 (25.5, 112.0) 78.0 (39.0, 110.5) 0.298 0.008
Organ function indexes
 Blood glucose, mg/dL 9.85 (6.98, 12.18) 7.9 (6.95, 10.35) 0.311 9.4 (7.9, 11.3) 6.1 (5.7, 11.8) 0.118 0.057
 Lac, mmol/L 4.35 (3.20, 5.80) 2.2 (1.93, 3.75) 0.014 3.50 (2.75, 3.90) 1.3 (0.95, 1.90) 0.001 0.005
 pH 7.21 (6.94, 7.37) 7.31 (7.21, 7.38) 0.015 7.23 (7.07, 7.31) 7.39 (7.37, 7.44) 0.001 0.041
 Cr, μmol/L 58.0 (28.5, 79.8) 61.0 (54.5, 119.5) 0.121 48.0 (28.0, 77.0) 38.0 (20.5, 72.0) 0.517 0.023
 ALT, IU/L 36.0 (19.8, 63.3) 63.0 (27.0, 140.8) 0.048 35.0 (12.5, 70.0) 38.0 (26.0, 52.0) 0.227 0.170
Catecholamine
 Adrenalin, ng/L 153.6 (127.0, 184.4) 145.4 (85.8, 175.1) 0.190 169.8 (145.5, 244.6) 148.0 (109.0, 208.1) 0.033 0.223
 Dopamine, ng/L 127 (82.4, 156.5) 133.4 (83.0, 171.7) 0.678 152.7 (97.0, 191.1) 96.0 (68.0, 160.9) 0.026 0.319
RAAS substances
 Renin, μg/L.h 2.35 (1.49, 4.76) 2.90 (1.30, 4.80) 0.872 1.12 (0.74, 3.45) 0.79 (0.52, 1.25) 0.029 0.003
 AngiotensinII, ng/L 348.4 (131.5, 773.0) 565.4 (210.9, 773.3) 0.215 185.9 (125.2, 800.0) 106.0 (90.8, 232.5) 0.047 0.001
 Aldosterone, ng/L 211.2 (119.8, 362.6) 281.9 (167.9, 349.0) 0.730 165.7 (94.0, 353.3) 103.3 (84.3, 144.3) 0.033 0.001
  1. LVEF Left ventricular ejection fraction, CI Cardiac index, cTnI Cardiac troponin I, CK-MB Creatine kinase-MB, Lac Lactate, Cr Creatinine, ALT Alanine transaminase. Continuous variables were summarized as the median (IQR). P indicates A1 vs. A2; P′ indicates B1 vs. B2; P″ indicates A2 vs. B2