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Table 1 Case definition for invasive meningococcal disease, used for notification to the national level in the Netherlands (OSIRIS)

From: Evaluation of the surveillance system for invasive meningococcal disease (IMD) in the Netherlands, 2004–2016

A person with at least one of the following symptoms:
• Fever
• Neck stiffness
• Petechiae
• Septic shock
• Septic arthritis
In combination with at least one of the following laboratory criteria:
• Detection of N. meningitidis by culture of normally sterile material (e.g. blood or cerebrospinal fluid (CSF))
• Detection of gram-negative diplococci in CSF, blood or biopsy of petechiae
• Detection of DNA of N. meningitidis by PCR of normally sterile material (e.g. blood or CSF)
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