CD40 polymorphisms were associated with HCV infection susceptibility among Chinese population

BMC Infectious Diseases

Table 3 Stratified analysis of rs1535045 and rs1883832 among control, spontaneous clearance and persistent infection groups

SNPs	Allele	Subgroups	Group (B + C)/Group A
SNPs	Allele	Subgroups	OR(95%CI)^a	P ^a	P ^b
rs1535045	C/T	Age
		<50	1.417 (0.973-2.064)	0.069	0.787
		≥50	1.323 (0.955-1.832)	0.092	0.787
		Gender
		male	1.240 (0.764-1.652)	0.551	0.158
		female	1.639 (1.181-1.274)	0.003	0.158
		Routes of infection
		HD	1.285 (0.684-2.413)	0.436	0.479
		Drug user	0.985 (0.607-1.598)	0.951
		PBD	1.418 (1.013-1.985)	0.042
rs1883832	C/T	Age
		<50	1.485 (1.020-2.162)	0.039	0.572
		≥50	1.297 (0.979-1.719)	0.070	0.572
		Gender
		male	1.532 (1.077-2.180)	0.018	0.344
		female	1.228 (0.917-1.646)	0.168	0.344
		Routes of infection
		HD	2.042 (1.225-3.404)	0.006	0.066
		Drug user	1.836 (1.021-3.304)	0.043
		PBD	1.111 (0.839 -1.471)	0.168

Abbreviations: CI confidence interval, HD hemodialysis, PBD paid blood donors, OR odds ratio
Group A: controls; Group B: spontaneous clearance subjects; Group C: persistent infection patients. Group (B + C): HCV-infected individuals
^a The P value, OR and 95% CIs of group (B + C) versus Group A were calculated on the basis of the binary logistic regression model, adjusted by gender, age and routes of infection in recessive model (TT versus [TC + CC])
^b The P value for the heterogeneity test
Bold type indicates statistically significant results

ISSN: 1471-2334